Clinical Research Directory

Key Inclusion Criteria * Histologically or cytologically confirmed advanced or metastatic NSCLC. 1. Cohort A: Histologically or cytologically confirmed non-squamous NSCLC. 2. Cohort B: Histologically or cytologically confirmed squamous NSCLC. * Confirmed NECTIN4 gene amplification by an analytically validated clinical trial assay. * Participants must have received at least 1 prior line of systemic therapy in the advanced/metastatic setting. * Participants with no known actionable genomic alterations must have received both platinum based therapy and immunotherapy given either sequentially or in combination for advanced/metastatic NSCLC. Must not have received more than 3 prior lines of systemic therapy in the advanced/metastatic setting. * Participants with known actionable genomic alterations (eg, EGFR, ALK, BRAF, MET, ROS1, NTRK1/2/3, RET, etc.) are eligible provided they have received or are not candidates for available standard targeted therapy in the advanced/metastatic setting. * Measurable disease as defined by RECIST v1.1. * Adequate archival or fresh tumor tissue comprised of advanced or metastatic NSCLC should be available for submission to central laboratory, if not provided during prescreening. * Life expectancy ≥ 12 weeks. * Eastern Cooperative Oncology Group Performance Status of ≤ 1. Key Exclusion Criteria * Evidence of mixed small cell lung cancer (SCLC) and NSCLC histology. * Prior treatment with monomethyl auristatin E (MMAE) (vedotin) based therapy. * Known hypersensitivity or allergy to any of the ingredients of any of the study interventions, or to MMAE. * Ongoing clinically significant toxicity (Grade ≥ 2) associated with prior treatment for NSCLC (including radiotherapy or surgery), with the exception of well-controlled immuno-oncology related endocrine disorders on supportive or replacement therapy, and alopecia. (Note: Immunosuppressive therapies should be stopped or tapered down to ≤10 mg/day prednisone or equivalent before first study drug administration.) * Active keratitis or corneal ulcerations. * Active or untreated central nervous system (CNS) metastases. * Uncontrolled diabetes or hypertension. * Uncontrolled pleural effusion, pericardial effusion, or ascites requiring recurrent draining procedures (monthly or more frequently). * Active interstitial lung disease or pneumonitis requiring ongoing treatment with steroids (\>10mg/day of prednisone or equivalent) or other immunosuppressive medications; or any prior history of ILD or non-infectious pneumonitis requiring high-dose glucocorticoids. * History of another active malignancy, except adequately resected non-melanoma skin cancer, curatively treated in situ disease, or other malignancies curatively treated with no evidence of disease for ≥3 years. * Known requirement, while on study, for treatment with strong inhibitors or strong inducers of human cytochrome P450 3A (\[cytochrome P450 3A\] CYP3A) including herbal- or food-based inhibitors/inducers. * Prior treatment with any systemic anticancer therapy within 28 days or 5 half-lives, whichever is shorter, prior to first dose of study treatment. Note: Additional protocol defined Inclusion/Exclusion criteria apply