Clinical Research Directory

Inclusion Criteria: * Patients diagnosed with inflammatory demyelinating diseases of the central nervous system, such as neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS) * Hamilton Anxiety Scale (HAM-A) score \> 14 * Aged between 18 and 65 years, with no gender restrictions * Receiving stable doses of immunosuppressive therapy for at least one month * Expanded Disability Status Scale (EDSS) score ≤ 6 * Right-handed * Willing to participate and sign informed consent Exclusion Criteria: * Recorded relapse within the past month * Recent medication adjustments or treatments involving modified electroconvulsive therapy, transcranial magnetic stimulation, or other neuromodulation techniques within the past month * Participation in any other clinical study within the past month or currently * Presence of cochlear implants, cardiac pacemakers, or implanted stimulators in the brain * Impaired skin integrity at the electrode placement site or allergies to electrode gel or adhesives * History of epilepsy, hydrocephalus, central nervous system tumors, brain injury, or intracranial infections * Pregnant or breastfeeding women, or those planning to conceive in the near future * Hamilton Depression Scale suicide item score ≥ 3 or comorbid severe mental disorders * Presence of severe or unstable organic diseases * Poor compliance preventing cooperation with treatment, follow-up, or clinical, EEG, and imaging data collection * Any condition deemed unsuitable for study participation by the investigator