Clinical Research Directory
Browse clinical research sites, groups, and studies.
Temple Health Chest Initiative (THCI 2.0)
Sponsor: Temple University
Summary
Chronic obstructive pulmonary disease is highly prevalent globally, with considerable morbidity and mortality associated. In the US, it is the 4th leading cause of death, as well as contributing to significant costs on healthcare utilization including hospitalization. Population-based screening for COPD has not been recommended by the US Preventative Services Task Force (USPSTF). However, LDCT screening for lung cancer in patients aged 50- 80 with ≥ 20 pack year smoking has been shown to improve survival. COPD is highly prevalent within LCS programs, with estimated rates of obstructive lung function of up to 59% and evidence of emphysema on CT scan in around 70%.
Official title: Temple Health Chest Initiative (THCI 2.0) - Lung Cancer Screening Project With COPD Detection
Key Details
Gender
All
Age Range
50 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
1000
Start Date
2025-02-28
Completion Date
2026-06-30
Last Updated
2025-04-18
Healthy Volunteers
Yes
Interventions
Determine COPD prevalence utilizing spirometry along with CT scans and symptom assessments in the THCI lung cancer screening populatio
Demonstrate utility of LDCT in COPD characterization Determine exacerbation risk and symptom burden in this patient population Determine the severity of COPD identified through this process Describe phenotypic characteristics including imaging analysis of THCI population Determine the suitability and acceptance of patients to participate in COPD clinical trials Determine the incidence of comorbid lung (ILA, bronchiectasis, pulmonary artery enlargement) and non-lung problems (cardiac and aortic calcifications, osteopenia/osteoporosis and for gut abnormalities) identified by LDCT in a patient population at risk for lung cancer and/or COPD Determine the correlation between clinical measurements and imaging biomarkers
Locations (1)
Temple University Of the Commonwealth System of Higher Education
Philadelphia, Pennsylvania, United States