Clinical Research Directory

Inclusion Criteria: * Participant or legal guardian provides written informed consent. * Age ≥18 and ≤80 years, regardless of gender. * De novo target lesion located in the native superficial femoral, popliteal, or infrapopliteal artery. * Life expectancy \>1 year as assessed by the investigator. * Candidate suitable for endovascular angiography and intervention per investigator judgment. * Willingness to undergo Chocolate Balloon Catheter PTA. Exclusion Criteria: * Active systemic infection or uncontrolled coagulation disorder within 14 days prior to procedure. * Planned major amputation of the target limb (at or above the ankle). * Renal insufficiency (MDRD eGFR ≤30 mL/min/1.73 m²) or serum creatinine ≥2.5 mg/dL within 30 days, or dialysis dependence. * Contraindication to antiplatelet therapy (aspirin/clopidogrel), low-molecular-weight heparin, vasodilators, or contrast agents. * Uncontrolled systemic comorbidities (e.g., severe cardiac/pulmonary/hepatic dysfunction, advanced malignancy, uncorrected coagulopathy). * History of cerebral hemorrhage, symptomatic stroke, myocardial infarction, or gastrointestinal bleeding within 6 months. * Pregnancy, lactation, or planned pregnancy (men or women). * Participation in another interventional clinical trial with unmet primary endpoint. * Investigator-determined medical, social, or psychological contraindications. * Life expectancy \<1 year.