Clinical Research Directory

Browse clinical research sites, groups, and studies.

Sites Groups Studies

Back to Studies

RECRUITING

NCT06936618

EIT-Guided Ventilator Settings in AHRF

Sponsor: Mahidol University

View on ClinicalTrials.gov

Summary

This exploratory study aims to investigate the effect of Electrical Impedance Tomography (EIT)-guided ventilator settings on mechanical power in patients with acute hypoxemic respiratory failure (AHRF), including both ARDS and non-ARDS conditions. Mechanical power, a key factor associated with ventilator-induced lung injury (VILI), will be measured before and after EIT-guided PEEP titration. The study will evaluate feasibility and changes in lung mechanics, gas exchange, and EIT parameters. A total of 17 patients requiring invasive mechanical ventilation will be enrolled at Siriraj Hospital, Mahidol University.

Official title: Using Electrical Impedance Tomography-Guided Ventilator Settings to Reduce Mechanical Power in Acute Hypoxemic Respiratory Failure : An Exploratory Study

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

Start Date

2024-12-17

Completion Date

2026-12

Last Updated

2025-04-27

Healthy Volunteers

Conditions

Acute Hypoxemic Respiratory Failure Acute Respiratory Distress Syndrome (ARDS)Mechanical Power Ventilator Induced Lung Injury Electrical Impedance Tomography (EIT)

Interventions

DEVICE

Electrical Impedance Tomography (EIT), Enlight 2100

Patients will undergo ventilator adjustments using EIT-guided PEEP titration to optimize mechanical power and lung mechanics.

Inclusion Criteria: * Age ≥ 18 years * Diagnosed with acute hypoxemic respiratory failure within 48 hours * Expected to require invasive mechanical ventilation ≥ 48 hours * On mechanical ventilation within 24 hours * Deep sedation and neuromuscular blockade Exclusion Criteria: * Pregnancy * Body mass index (BMI) \> 40 kg/m2 * Contraindications to using electrical impedance tomography, including * Presence of a pacemaker or automatic implantable cardioverter-defibrillator (AICD) * Inability to place the belt due to presence of surgical wounds dressing, thoracic or spinal cord trauma, recent thoracic surgery, etc. * High risk for PEEP titration * Hemodynamic instability defined as mean arterial pressure \< 65 mmHg despite optimization of fluid status and/or use of vasopressors * Unstable cardiac arrhythmias * Presence of lung bullae greater than 2 cm in diameter, identified on chest X-ray * Presence of pneumothorax or pneumomediastinum * Right-sided heart failure or severe pulmonary hypertension * Neurologic conditions associated with a risk of intracranial hypertension * Use of extracorporeal membrane oxygenation (ECMO) * Severe chronic respiratory disease, defined as follows: requiring home oxygen therapy, or previous lung function showing (FEV1 less than 20 ml/kg PBW, or FEV1/FVC less than 50% predicted value), or chronic hypercapnia (PaCO2 greater than 45 mmHg) and/or chronic hypoxemia (PaO2 less than 55 mmHg) on FIO2 = 0.21, or radiographic x-ray evidence of any chronic over-inflation or chronic interstitial infiltration, or chronic restrictive, obstructive, neuromuscular, chest wall or pulmonary vascular disease resulting in severe exercise restriction (unable to climb stairs or perform household duties, secondary polycythemia, severe pulmonary hypertension with mean pulmonary arterial pressure greater than 40 mmHg) * Decision to withhold life-sustaining treatment or palliative care. * Moribund status with an expected survival of less than 24 hours. * Refusal to provide informed consent

Locations (1)

Siriraj Hospital, Mahidol University

Bangkok, Thailand