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Preventive Effect of Probiotics in GDM
Sponsor: Women's Hospital School Of Medicine Zhejiang University
Summary
Gut microbiota is instrumental in the microbial and metabolic network of pregnant women, and is potentially related with gestational diabetes. Perinatal probiotic intervention contributes to improved glucose regulation during pregnancy. Our randomized, double-centered, placebo-controlled study is planned to recruit 334 pregnant women who is in high risk for gestational diabetes. They will be assumed randomly probiotic powder per day or placebo from 12-16th gestational weeks until Oral Glucose Tolerance Test (OGTT) at 24-28th gestational weeks. Perinatal outcomes about neonatal weight will be registered.
Official title: The Preventive Effect of Probiotics in Pregnant Women With High-risk for Gestational Diabetes
Key Details
Gender
FEMALE
Age Range
18 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
334
Start Date
2023-10-27
Completion Date
2026-11-01
Last Updated
2025-04-27
Healthy Volunteers
No
Conditions
Interventions
Probiotics
Probiotics powder including: Resistant dextrin, inulin, oligosaccharide, erythritol, Lactobacillus plantarum VB165, Bifidobacterium lactis VB301, Lactobacillus rhamnosus VB255, acerola cherry powder, citric acid
Placebo
placebo with similar appearance and smell but not containing probiotics
Locations (1)
Women's Hospital Zhejiang University School of Medicine
Hangzhou, Zhejiang, China