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How Bleeding Affects Delirium in Older Patients With Hip Fractures: The IMPROVE-HIP Study
Sponsor: University of Aarhus
Summary
The goal of this clinical trial is to investigate whether early detection of bleeding and prompt blood transfusions can help prevent delirium in patients aged 75 and older who are admitted to the hospital with hip fractures. The main question the trial aims to answer is: Do patients aged 75 and older with hip fractures benefit from earlier treatment of anemia (low blood count) to reduce the risk of delirium? Researchers will compare early diagnosis and treatment of bleeding with standard care to determine if it helps lower the risk of developing delirium. Participants will: Undergo blood tests, have their vital signs monitored, and be screened for delirium three times a day for the first 48 hours after surgery. Receive blood transfusions promptly if their hemoglobin levels fall below a specified threshold. Attend a follow-up visit at 30 days to assess cognitive function and overall quality of life. Attend another follow-up at 90 days to evaluate hospital readmissions and survival.
Official title: The Impact of Bleeding on Delirium Outcomes in Older Patients With Hip Fractures: A Single-Blind, Randomized Controlled Trial - The IMPROVE-HIP Study
Key Details
Gender
All
Age Range
75 Years - Any
Study Type
INTERVENTIONAL
Enrollment
198
Start Date
2025-04-24
Completion Date
2027-06-01
Last Updated
2026-05-22
Healthy Volunteers
No
Interventions
Blood Transfusion
Blood transfusion is given without delay (within 4 hours) in case of hemoglobin below our threshold.
Standard care
These patients recieve our standard care including blood transfusion as usual. Vital parameters and delirium screening are collected three times a day.
Locations (2)
Aarhus University Hospital
Aarhus, Central Jutland, Denmark
Gødstrup Hospital, Department of internal medicine
Herning, Central Jutland, Denmark