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RECRUITING
NCT06940609
PHASE2

Magnetic Resonance Analysis of Neural Inflammatory Factors and External Stimulation

Sponsor: University of New Mexico

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to test whether a type of rapid outpatient brain stimulation that uses magnetic fields, called accelerated intermittent theta burst stimulation (iTBS), can treat symptoms such as brain fog, depression, and anxiety in patients with Long COVID. The main questions it aims to answer are: * Is iTBS effective and feasible for reducing Long COVID symptoms? We will measure these symptoms using the Symptom Burden Questionnaire. * Are there changes in inflammatory brain chemicals associated with treatment with iTBS? We will be looking at levels of choline in the brain, which is thought to be related to inflammation. Researchers will compare sham versus active forms of iTBS to see if the active group has greater improvement in symptoms. Participants will complete symptom surveys, cognitive tests, and magnetic resonance imaging scans at the beginning, middle, and end of treatment.

Official title: Magnetic Resonance Analysis of Neural Inflammatory Factors and External Stimulation (MANIFEST)

Key Details

Gender

All

Age Range

18 Years - 80 Years

Study Type

INTERVENTIONAL

Enrollment

60

Start Date

2025-07-07

Completion Date

2029-06-30

Last Updated

2025-07-15

Healthy Volunteers

No

Interventions

DEVICE

accelerated intermittent theta burst stimulation

Intermittent theta burst stimulation (iTBS), a FDA-approved form of noninvasive neuromodulation, can reduce neuropsychiatric symptoms and modulate inflammation in the thalamus as detected using dMRS, suggesting a potentially effective and efficient treatment approach with a pathophysiological component that is readily quantifiable.

Locations (1)

University of New Mexico Health Science Center

Albuquerque, New Mexico, United States