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Chloride Imbalance in Preterm Infants
Sponsor: Kanuni Sultan Suleyman Training and Research Hospital
Summary
In adults and children low or high blood chloride levels are linked to the risk of death. The aim of this observational study is to determine whether there is a relationship between low or high blood chloride levels and the risk of death or long-term lung problems. We will also learn the risk factors and associated conditions of high or low blood chloride levels. We will include infants born before 32 weeks of pregnancy or have a birth weight of less than 1500 grams in the study. The main question it aims to answer is: Is there a relationship between low or high blood chloride levels in the first 4-6 weeks of life and risk of death or long-term lung problems in premature babies? We will examine the medical reports of babies who were followed up in neonatal intensive care unit over the past 5 years.
Official title: The Impact of Chloride Imbalance on BPD Development and Mortality in Preterm Infants
Key Details
Gender
All
Age Range
1 Hour - 6 Weeks
Study Type
OBSERVATIONAL
Enrollment
500
Start Date
2025-04-15
Completion Date
2026-10-15
Last Updated
2025-04-23
Healthy Volunteers
No
Interventions
Incomplete response
Infants died before 36 weeks PMA, infants diagnosed to have BPD at 36 weeks PMA and infants developed major complications before 36 weeks PMA: 1. \>Stage 2 necrotizing enterocolitis according to Bell classification 2. Hemodynamically significant patent ductus arteriosus 3. \>Grade 2 intraventricular hemorrhage, 4. Retinopathy of prematurity, ICROP classification stage \>2 5. \>Stage 2 cystic periventricular leukomalacia 6. Ventricular dilatation/hydrocephalus requiring intervention
Complete response
Infants discharged before 36 weeks PMA and infants who reached 36 weeks PMA without BPD and major complications: 1. \>Stage 2 necrotizing enterocolitis according to Bell classification 2. Hemodynamically significant patent ductus arteriosus 3. \>Grade 2 intraventricular hemorrhage, 4. Retinopathy of prematurity, ICROP classification stage \>2 5. \>Stage 2 cystic periventricular leukomalacia 6. Ventricular dilatation/hydrocephalus requiring intervention
Bad response
Infants died before 36 weeks PMA and infants diagnosed to have BPD at 36 weeks PMA
Locations (1)
Kanuni Sultan Suleyman Education and Research Hospital
Istanbul, Turkey, Turkey (Türkiye)