Clinical Research Directory

Inclusion Criteria: 1. Age 60 to 85 years of age 2. Non-complex, non-comminuted fracture of the femoral head, femoral neck, or acetabulum due to an accidental (non-neurologic or cardiovascular) fall 3. Concomitant medication limited to treatment for chronic conditions 4. The ability to give informed consent and comply with study procedures 5. Body weight ≥35 kg 6. Adequate dietary intake 7. Potential subjects' intention to avoid reproductive activity will be confirmed And one or more of the following criteria: 8. Previous history frailty or sarcopenia diagnosis using standardized tests; 9. Positive assessment for frailty or sarcopenia using standardized tests or as per clinician's judgement; 10. Previous positive assessment for elevated biomarkers of inflammation (serum IL-6 level\> LOQ, TNFR1 level \> LOQ, and/or TNF-alpha level \> LOQ) Exclusion Criteria: 1. Receiving immunotherapy for cancer or solid organ transplantation 2. Complex or comminuted fracture or fracture of multiple long bones 3. Regular treatment for chronic disease including chronic renal failure, chronic heart failure (CHF) cerebrovascular disease including stroke, rheumatoid arthritis, or polymyalgia rheumatica 4. Chronic kidney disease (estimated glomerular filtration rate \[eGFR\] \<60 mL/min) 5. Newly (\< 2 weeks) diagnosed COVID-19 6. Inability or unwillingness to give written informed consent 7. History of upper/lower respiratory tract infection, requiring systemic steroids, antibiotics, and or emergency room (ER) visit or urgent care within 6 weeks of screening visit 8. History of adverse reaction or allergy to TNF inhibitor 9. History of neurological, hepatic, renal, diabetic mellitus, thyroid disorder, psychiatric, addiction or other medical conditions that may interfere with the interpretation of data or the patient's participation in the study or may increase safety concerns per investigator discretion 10. Currently under treatment by an anti-TNFα drug, such as adalimumab, etanercept, infliximab, certolizumab pegol, golimumab, and biosimilars 11. Currently under treatment by an anti-diabetic medication, including glucagon-like peptide-1 (GLP-1) drugs such as semaglutide, or any of metformin, jenuvia, or insulin 12. Unwillingness or inability to comply with study procedures, including smoking cessation 13. History of epilepsy or seizure propensity, ataxia, abnormal EEG findings, abnormal brain magnetic resonance image, or other co-morbid neurological conditions 14. Positive TB test 15. Patients who are pregnant or breastfeeding