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Study of Probiotics Combined With Concurrent Hyperfractionated ChemoRadiotherapy and Adebrelimab Immunomaintenance in the Treatment of Limited-stage Small Cell Lung Cancer (LS-SCLC)
Sponsor: Fudan University
Summary
ADRIATIC study explored the benefits of immune maintenance therapy after LS-SCLC radiotherapy and chemotherapy. In the presence of immunotherapy, is it necessary to increase the dosage of radiotherapy and can it further improve the efficacy? This study aims to explore the efficacy and safety of simultaneous integrated boost hyperfractionation radiotherapy combined with probiotics and Adalberg monoclonal antibody consolidation therapy for small cell lung cancer.
Official title: A Prospective, Multicenter, Randomized Controlled, Phase II Study of Probiotics Combined With Concurrent Hyperfractionated ChemoRadiotherapy and Adebrelimab Immunomaintenance in the Treatment of Limited-stage Small Cell Lung Cancer (LS-SCLC)
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2025-04-25
Completion Date
2027-12-30
Last Updated
2026-02-11
Healthy Volunteers
No
Conditions
Interventions
Probiotics
Subjects received probiotics before radiotherapy
concurrent Hyperfractionated Radiotherapy
Increase radiation dose on the basis of conventional radiotherapy
Immunotherapy
Adebrelimab, 1200mg，q3w，2 year
Locations (1)
Fudan University Shanghai Cancer Center
Shanghai, Shanghai Municipality, China