Inclusion Criteria:
1. Healthy men or women 18 to 55 years of age
2. BMI between 18 and 32 kg/m2
3. Negative serum pregnancy test
4. Use of highly effective birth control method(s) for a minimum of 60 days prior to consent and is willing to continue use for at least 12 months, or abstinence
5. In good general health as determined by medical history, exams and tests
Exclusion Criteria:
1. Acute illness or fever (≥100.4°F) within 7 days prior to dosing
2. Any history of receiving treatment, vaccine, or monoclonal antibodies (mAbs) against the Yersinia pestis bacterium
3. Receipt of any vaccine within 30 days prior to Screening, planned receipt of any vaccine prior to Day 1, or planned receipt of any vaccines before 45 days post-injection.
4. Any medical condition for which IM injections would be contraindicated in the opinion of the investigator (eg, bleeding disorders, anticoagulant therapy, and severe thrombocytopenia)
5. History of congenital or acquired immunodeficiency syndrome
6. Prior solid organ or bone marrow transplant
7. Use of systemic steroids, immunosuppressive agents, anticoagulants, or antiarrhythmics within 1 year prior. A single short course (ie, less than 14 days) is allowed provided it is concluded more than 6 months prior to Screening
8. Upper arm is with insufficient muscular tissue for IM injections or is obscured by tattoos or rash that may preclude accurate assessment of injection site reactions
9. Use of any medications started within 30 days prior to Day -1, including prescription medications, nutritional supplements, and over-the-counter medications
* Vitamin supplements are allowed
* Recommended doses of acetaminophen are allowed, except for 24 hours prior to dosing
* Recommended doses of non-steroidal anti-inflammatory drugs (NSAIDs) (eg, aspirin, ibuprofen) are also allowed, except for 7 days prior to dosing
10. Positive human immunodeficiency virus (HIV-1/-2) antibody result by history or at Screening
11. Positive hepatitis B surface antigen, hepatitis B core antigen, or hepatitis C antibody
12. Positive urine drug test or cotinine (indicating active current smoking) at Screening or Day -1, positive alcohol breath test at Screening or on Day -1, or suspected/known drug abuse and/or alcohol use disorder
13. Smoking or has used nicotine or nicotine-containing products (eg, snuff, nicotine patch, nicotine chewing gum, mock cigarettes, or inhalers) within 3 months before study drug dosing
14. Dosing in any clinical research study evaluating another investigational drug or therapy within 30 days or at least 5 half-lives (whichever is longer) of receiving the investigational drug prior to Screening
15. Progressive, unstable, or uncontrolled medical conditions that have required medical attention or changes to medication for medical reasons within 90 days prior to consent
16. History of allergic reactions or hypersensitivity reactions to other therapeutic antibodies or immunoglobulins
17. Receipt of any mAbs in the 12 months prior to Screening
18. High blood pressure
19. History of hyperprolinemia
20. Women who are either pregnant or breast-feeding
21. Vulnerable individuals (eg, military recruits, persons in compulsory detention, those with limited legal capacity)
22. Receipt of immunoglobulins or any blood products within 90 days prior to consent or planned receipt during the study period
23. Donation or loss of \>500 mL of blood within 30 days or plasma within 7 days of Day 1; any planned donation of blood or plasma during the study period
24. History of any malignant neoplasm within the last 5 years, with the exception of adequately treated localized or in situ non-melanoma carcinoma of the skin or the cervix
25. Strenuous activity or contact sports within 48 hours before study drug dosing and through Day 8
26. History of relevant drug and/or food allergies
