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Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors
Sponsor: Exelixis
Summary
The primary purpose of this study is to assess the effectiveness of zanzalintinib compared to everolimus in participants with previously treated, unresectable, locally advanced or metastatic neuroendocrine tumors.
Official title: A Phase 2/3, Multicenter, Randomized Open-Label Study of Zanzalintinib vs Everolimus in Participants With Previously Treated, Unresectable, Locally Advanced or Metastatic Neuroendocrine Tumors
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
440
Start Date
2025-07-21
Completion Date
2029-06-30
Last Updated
2026-07-09
Healthy Volunteers
No
Interventions
Zanzalintinib
Administered as specified in the treatment arm.
Everolimus
Administered as specified in the treatment arm.
Locations (97)
The University of Alabama at Birmingham
Birmingham, Alabama, United States
Mayo Clinic Hospital
Phoenix, Arizona, United States
The University of Arizona Cancer Center
Tucson, Arizona, United States
Cedars-Sinai Medical Center
Beverly Hills, California, United States
Norris Comprehensive Cancer Center
Los Angeles, California, United States
Stanford Cancer Center
Palo Alto, California, United States
UCLA Health - Santa Monica Cancer Care
Santa Monica, California, United States
Kaiser Permanente Medical Center
Vallejo, California, United States
Georgetown University
Washington D.C., District of Columbia, United States
Mayo Clinic - Florida
Jacksonville, Florida, United States
AdventHealth Orlando
Orlando, Florida, United States
Moffitt Cancer Center
Tampa, Florida, United States
University of Kentucky Markey Cancer Center
Lexington, Kentucky, United States
East Jefferson General Hospital
Metairie, Louisiana, United States
Dana-Farber Cancer Institute
Boston, Massachusetts, United States
Henry Ford Caner- Detroit
Detroit, Michigan, United States
The Cancer and Hematology Centers
Grand Rapids, Michigan, United States
Mayo Clinic
Rochester, Minnesota, United States
Siteman Cancer Center
St Louis, Missouri, United States
University of Nebraska Medical Center
Omaha, Nebraska, United States
University of New Mexico Comprehensive Cancer Center
Albuquerque, New Mexico, United States
Roswell Park Cancer Institute
Buffalo, New York, United States
Icahan School of Medicine at Mount Sinai
New York, New York, United States
University of Rochester Medical Center
Rochester, New York, United States
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States
Duke University Medical Center
Durham, North Carolina, United States
Sanford Roger Maris Cancer Center
Fargo, North Dakota, United States
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States
The Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States
Oregon Health and Science University
Portland, Oregon, United States
University of Pennsylvania
Philadelphia, Pennsylvania, United States
University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center
Pittsburgh, Pennsylvania, United States
University of Tennessee Medical Center
Knoxville, Tennessee, United States
Henry-Joyce Cancer Clinic
Nashville, Tennessee, United States
Texas Oncology- Baylor Charles A. Sammons Cancer Center
Dallas, Texas, United States
Huntsman Cancer Institute, University of Utah
Salt Lake City, Utah, United States
University of Virginia
Charlottesville, Virginia, United States
Virginia Cancer Specialists - Fairfax Office
Fairfax, Virginia, United States
Fred Hutchinson Cancer Center
Seattle, Washington, United States
Froedtert Hospital and the Medical College of Wisconsin
Milwaukee, Wisconsin, United States
Monash Health
Clayton, Australia
Royal Brisbane and Women's Hospital
Herston, Australia
Fiona Stanley Hospital
Murdoch, Australia
GenesisCare North Shore
St Leonards, Australia
The Queen Elizabeth Hospital
Woodville South, Australia
Medical University of Graz
Graz, Austria
Paracelsus Medical University Hospital Salzburg
Salzburg, Austria
Cliniques Universitaires Saint-Luc (UCLouvain)
Woluwe-Saint-Lambert, Belgium
Verspeeten Family Cancer Center - London Health Sciences Centre
London, Canada
The Ottawa Hospital Cancer Center
Ottawa, Canada
Sunnybrook Health Sciences Centre
Toronto, Canada
Humanity and Health Clinical Trial Centre
Hong Kong, China
Prince of Wales Hospital
Hong Kong, China
Queen Mary Hospital
Hong Kong, China
CHU de Montpellier Hôpital Saint Eloi
Montpellier, France
Gustave Roussy
Villejuif, France
Evangelische Lungenklinik
Berlin, Germany
Universitätsklinikum Gießen und Marburg GmbH, Standort Marburg
Marburg, Germany
Universitätsklinikum Tübingen
Tübingen, Germany
University Hospital Würzburg
Würzburg, Germany
Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori IRST s.r.l.
Meldola, Italy
Instituto Europeo di Oncologia
Milan, Italy
Istituto Nazionale Tumori IRCCS - Fondazione Pascale
Naples, Italy
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
Palermo, Italy
Azienda Ospedaliero-Universitaria Policlinico Umberto I
Roma, Italy
Het Netherlands Kanker Institut (NKI)/ Antoni van Leeuwenhoek
Amsterdam, Netherlands
Maastricht Universitair Medisch Centrum
Maastricht, Netherlands
Maxima Medisch Centrum
Veldhoven, Netherlands
Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy, Oddział w Gliwicach
Gliwice, Poland
Śląskiego Uniwersytet Medyczny w Katowicach
Katowice, Poland
Samodzielny Publiczny Zakład Opieki Zdrowotnej Szpital Uniwesytecki w Krakowie
Krakow, Poland
Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy
Warsaw, Poland
FutureMeds Wrocław
Wroclaw, Poland
Pan American Center for Oncology Trials, LLC
San Juan, Puerto Rico
FDI Clinical Resesarch
San Juan, Puerto Rico
Korea University Anam Hospital
Seoul, South Korea
Seoul National University Hospital
Seoul, South Korea
Severence Hospital, Yonsei University Health System
Seoul, South Korea
Asan Medical Center
Seoul, South Korea
Samsung Medical Center
Seoul, South Korea
Hospital Universitario Vall D'Hebron
Barcelona, Spain
Hospital Universitario Ramón y Cajal
Madrid, Spain
Hospital Universitario 12 de Octubre
Madrid, Spain
Hospital Universitario La Paz
Madrid, Spain
Hospital General Universitario J.M Morales Meseguer
Murcia, Spain
Hospital Universitario Central de Asturias
Oviedo, Spain
Hospital Universitario Marqués de Valdecilla
Santander, Spain
Hospital Clínico Universitario de Santiago de Compostela
Santiago de Compostela, Spain
Hospital Universitario Vigen Del Rocío
Seville, Spain
Hospital Universitario y Politécnico La Fe
Valencia, Spain
Hospital Universitario Miguel Servet
Zaragoza, Spain
The Clatterbridge Cancer Centre
Liverpool, United Kingdom
Guy's and St Thomas' NHS Foundation Trust
London, United Kingdom
King's College Hospital NHS Foundation Trust
London, United Kingdom
Oxford University Hospitals NHS Foundation Trust
Oxford, United Kingdom
Sheffield Teaching Hospitals NHS Foundation Trust
Sheffield, United Kingdom
Swansea Bay University Health Board
Swansea, United Kingdom