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Milk Consumption and Blood Microbiome in Healthy Volunteers
Sponsor: Erasmus Medical Center
Summary
The goal of this study is to learn if cfDNA of milk-associated intestinal bacteria (MAIB) is detectable in the bloodstream. The primary question it aims to answer is: \- Does milk consumption simultaneously increase the number of MAIB cfDNA counts in blood samples, as it does in fecal samples? Researchers will compare cfDNA counts of MAIB to those of fecal samples to assess whether the blood microbiome is a valid measure of the gut microbiome, utilizing a self-developed bioinformatics pipeline. Participants will: * Abstain from consuming any dairy products for ten days, followed by drinking milk for 7 consecutive days. * Provide blood and fecal samples before dairy abstinence, as well as at 0, 24, and 48 hours, and one week after the reintroduction of milk.
Official title: The Effect of Milk Consumption on the Blood Microbiome in Healthy Volunteers
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
10
Start Date
2025-07-10
Completion Date
2025-09-15
Last Updated
2025-08-07
Healthy Volunteers
Yes
Conditions
Interventions
Milk product
The participants will abstain from consumption of any dairy product for ten days and subsequently drink milk for seven consecutive days (700 ml per day), while concomitant consumption of other dairy products is also allowed.
Locations (1)
Erasmus MC - Department of Gastroenterology and Hepatology
Rotterdam, Netherlands