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Study to Understand the Genetic Risk of Developing an Immune Response After Blood Transfusions Among Individuals With Sickle Cell Disease
Sponsor: National Human Genome Research Institute (NHGRI)
Summary
The purpose of this research study is to look at genes and determine how they interact with each other to find changes that could explain why some people's immune systems may respond to blood transfusions. This response is called an alloimmune response. We strongly believe that when someone has an alloimmune response, it is caused by changes in their genes. We plan to compare changes in the genes of individuals that develop red blood cell alloimmunization after blood transfusions with those that do not develop alloimmunization. This may help us to create more targeted therapeutic interventions, which may improve the health of alloimmune responders.
Official title: Observational Study to Determine Red Blood Cell Alloimmunization Risk Etiology in Patients With Sickle Cell Disease
Key Details
Gender
All
Age Range
2 Years - 99 Years
Study Type
OBSERVATIONAL
Enrollment
50
Start Date
2025-06-24
Completion Date
2030-04-10
Last Updated
2026-01-14
Healthy Volunteers
No
Conditions
Locations (1)
National Institutes of Health Clinical Center
Bethesda, Maryland, United States