Clinical Research Directory

Inclusion Criteria: * Adults aged 18-65 years; * Patients with complete or incomplete quadriplegia due to spinal cord injury, brainstem stroke, amyotrophic lateral sclerosis (ALS), or other motor neuron diseases, or those with bilateral upper limb amputations; * Normal motor cortex function confirmed by neurological assessment; * Muscle strength of bilateral or unilateral upper limbs ≤ Grade 3; * Patients who have received standardized treatment and met diagnostic criteria for at least 12 months before screening, with stable disease status for ≥6 months; * Expected lifespan ≥12 months; * Normal cognitive function; * Normal hearing and vision, or corrected vision to normal with standard lenses; * Patients with stable caregivers; * Willing to sign informed consent and able to comply with follow-up requirements. Exclusion Criteria: * Patients with neuropsychiatric disorders or psychological impairments; * Patients with brain MRI findings showing hemorrhage, tumors, anatomical abnormalities, or distortions; * History of severe systemic diseases (e.g., cardiac, pulmonary, hepatic, renal, thyroid, gastrointestinal, or hematologic disorders), poorly controlled diabetes, or pregnancy in females; * History of infectious diseases (e.g., syphilis, HIV), severe traumatic brain injury, or major surgeries; * Presence of metal implants or devices (e.g., cochlear implants, pacemakers, neurostimulators, defibrillators), except for dental implants or other implants deemed non-interfering; * Surgical or anesthesia contraindications as determined by surgeons or anesthesiologists; * Morbid obesity (BMI \>40); * Hearing impairment or uncorrectable visual deficits that would hinder prolonged computer monitor viewing; * Current participation in other clinical trials; * Other conditions considered unsuitable by investigators or medical staff.