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Pseudoexfoliation and Carpal Tunnel Study
Sponsor: Ankara Training and Research Hospital
Summary
This prospective, single-center case-control study aimed to investigate the association between pseudoexfoliation syndrome (PES) and carpal tunnel syndrome (CTS) using biochemical markers. A total of 159 participants aged 50-80 years were categorized into PES, CTS, and control groups. Diagnoses were confirmed by slit-lamp biomicroscopy for PES and electrophysiological evaluation (EMG) for CTS. Serum biomarkers, including homocysteine, methylmalonic acid, paraoxonase-1 (PON1), homocysteine thiolactonase (HTLase), and matrix metalloproteinases (MMP-2 and MMP-9), were measured. Group comparisons, diagnostic performance (ROC analysis), and independent associations (multinomial logistic regression) were evaluated. Comorbidities were recorded and analyzed in subgroup analyses.
Official title: The Relationship Between Ocular Pseudoexfoliation Syndrome and Carpal Tunnel Syndrome
Key Details
Gender
All
Age Range
50 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
159
Start Date
2025-05-01
Completion Date
2026-01-30
Last Updated
2026-04-17
Healthy Volunteers
Yes
Locations (1)
Department of Physical Therapy and Rehabilitation, University of Health Sciences, Ankara Training and Research Hospital
Ankara, Altindag, Turkey (Türkiye)