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Immunomodulatory Effects of NB-UVB and Steroids in Vitiligo: A Study on CXCL11 and TEMRA Biomarkers
Sponsor: Assiut University
Summary
this is a prospective, randomized controlled trial (RCT) investigating the immunological effects of narrowband UVB (NB-UVB) phototherapy-both as monotherapy and in combination with oral mini-pulse (OMP) steroids-in non-segmental vitiligo patients. The study evaluates changes in CXCL11 (a chemokine involved in T-cell recruitment) and TEMRA (terminally differentiated effector memory T cells re-expressing CD45RA) levels in serum before and after treatment.
Official title: Expression of CXCL11 & TEMRA in Serum of Vitiligo Patients Treated With Narrow-band UVB
Key Details
Gender
All
Age Range
Any - Any
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2025-09-01
Completion Date
2026-09-30
Last Updated
2025-04-27
Healthy Volunteers
No
Interventions
NB-UVB twice weekly
Standard phototherapy without additional systemic treatment.
NB-UVB + dexamethasone (2.5-3 mg/week)
Combination therapy to enhance immunosuppression and repigmentation.