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RECRUITING
NCT06946550
NA

Non-Ablative Laser to Treat Scarring Alopecia With Hair Follicle Gene Expression Analysis

Sponsor: Montefiore Medical Center

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to evaluate the effectiveness of a non-ablative 1470 nm laser in treating scarring alopecia in adults. The study will also investigate the biochemical molecular pathways involved in laser therapy by analyzing hair follicle gene expression before and after laser treatment. The main questions it aims to answer are: 1. Does a non-ablative laser work to effectively treat scarring alopecia? 2. What molecular pathways are associated with the laser's effects on hair follicles in scarring alopecia? Participants with scarring alopecia will: * Receive 3 laser treatments, spaced 1 month apart (Month 1, Month 2, Month 3), and attend 5 follow-up visits (Month 4, Month 6, Month 9, Month 12 and Month 15) * Have hair follicle samples collected via hair plucking of 10 hairs prior to the start and 1-month post-completion of laser treatments for gene expression analysis of inflammatory and fibrosis pathways implicated in scarring alopecia. Hair samples will be de-identified and kept anonymous. * Fill out questionnaires at each visit * Keep a diary of any side effects from laser treatments

Official title: 1470 nm Non-Ablative Laser for the Treatment of Scarring Alopecia: A Clinical and Mechanistic Study

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

5

Start Date

2025-12-09

Completion Date

2027-12

Last Updated

2025-12-15

Healthy Volunteers

Yes

Interventions

DEVICE

1470nm non-ablative fractional laser

Patients with scarring alopecia will be treated with the non-ablative Sciton HALO laser (1470nm).

Locations (1)

Montefiore Einstein Advanced Care

Elmsford, New York, United States