Clinical Research Directory

Inclusion Criteria: * Individuals between the ages of 18 and 65 years of age. * Patients undergoing a laparoscopic appendectomy. * Diagnosis of complicated appendicitis based on pre-operative imaging or intra-operative assessment. The definition of a complicated appendicitis will include: (a) perforated appendicitis, without generalized peritonitis; (b) gangrenous appendicitis, without generalized peritonitis; (c) suppurative appendicitis; (d) iatrogenic perforation of the appendix. * Meet criteria for discharge from the post-anesthesia care unit (PACU). * Ability to reliably follow up with the study procedures. Exclusion Criteria: * Age \< 18 years or \> 65 years. * Pregnancy. * Homelessness. * Patients who present with generalized peritonitis. * Patients with comorbid conditions, including diabetes mellitus, immunosuppressed state for any reason, patients on chronic anticoagulation (excluding Aspirin 81 mg). * Patients who present with septic shock. * Patients who require conversion to an open appendectomy. * Patients who present with additional findings on imaging studies or intra-operatively, including ileus or small bowel obstruction. * Based on surgeon's clinical judgment for reasons that may not be outlined above. * Allergy or intolerance to study medication(s)