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Acute Effects of THC in Older Adult
Sponsor: Yale University
Summary
The primary objective of this study is to determine if increasing age confers greater vulnerability to the acute A) cognitive (e.g., memory, attention, psychomotor function), B) subjective (e.g., anxiogenic and rewarding effects), and C) cardiovascular (heart rate and blood pressure), effects of THC in adults \> 21 years old. The secondary aims of the study are to explore age-related acute effects of THC on electrophysiological indices of information processing (e.g., auditory steady-state response (ASSR), oddball paradigm \[P300\], and resting state cortical noise) and to determine age-related differences in the metabolism of THC.
Key Details
Gender
All
Age Range
21 Years - Any
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2025-06-06
Completion Date
2027-11-01
Last Updated
2025-08-18
Healthy Volunteers
Yes
Conditions
Interventions
Delta-9-THC Low Dose
Active Delta-9-THC administered intravenously over 20 minutes.
Placebo
Small amount of sterile ethanol (1-2 mLs), with no THC, administered intravenously over 20 minutes.
Delta-9-THC Medium Dose
Active Delta-9-THC administered intravenously over 20 minutes
Locations (1)
VA Connecticut Healthcare System
West Haven, Connecticut, United States