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Clinical Investigation of Chemomechanical Parameters for an Efficient Disinfection of the Root Canal
Sponsor: National and Kapodistrian University of Athens
Summary
The aim of the study is first, to evaluate the clinical antibacterial efficacy of two different NaOCl concentrations (2,5% and 5%) under a predefined irrigant flow rate in teeth with pulp necrosis and apical periodontitis by using Real-time PCR. . Second, to evaluate the efficacy of final irrigation by assessing, if possible, a numerical definition for that "so called" as "copious irrigation". Besides the total microbial load, the antibacterial efficacy of final irrigation procedure against two different bacterial species (namely Pseudoramibacter alactolyticus and Treponema denticola) will also be examined.
Official title: Clinical Antibacterial Efficacy and Treatment Outcome After Implementing Various Root Canal Irrigating Procedures
Key Details
Gender
All
Age Range
Any - Any
Study Type
INTERVENTIONAL
Enrollment
44
Start Date
2023-12-01
Completion Date
2025-06-23
Last Updated
2025-05-11
Healthy Volunteers
Yes
Conditions
Interventions
Root canal tratment using mecchanical and chemical preparation.
Root canal procedures including access cavity preparation, chemomechanical instrumentation, irrigation with sodium hypoclorite (NaOCl), microbiological sampling and obturation with warm vertical compaction.
Sodium Hypochlorite.
Sodium Hypoclorite used as the primary irrigant in the root canal treatment at concentrations of 2.5% (Group A) and 5% (Group B).
Hydrogen peroxide.
Applied to the operating field and tooth as part of initial disinfection prior to cavity access.
Sodium Sulfate.
Used to inactivate sodium hypoclorite prior to sample collection.
Root ZX mini apex locator (Morita).
Used to determine the working length of the root canal.
Protaper Gold rotary files (Dentslpy Maillefer).
Used for coronal flaring in root canal instrumentation.
Smarttrack and Hyflex totary files.
Used for root canal instrumentation to full working length.
Endo-Eze 27G irrigation needle (Ultradent).
Used to deliver irrigant into the root canal.
Locations (1)
National and Kapodistrian University of Athens
Athens, Greece