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INcentives and ReMINDers to Improve Long-term Medication Adherence (INMIND)
Sponsor: RAND
Summary
Low medication adherence when initiating antiretroviral treatment (ART) is a key barrier to HIV virologic suppression, resulting in avoidable cases of drug resistance, death, and viral transmission. Routinized pill-taking can lead to successful long-term ART adherence, and short-term behavioral economics-based supports are a novel way to overcome the limited success of existing routinization interventions. This study proposes to test this combined approach for promoting long-term ART adherence using a Stage III Sequential, Multiple Assignment, Randomized Trial (SMART) design in one of the largest HIV clinics in Uganda to identify the most cost-effective adaptive intervention that if found effective is generalizable to other settings and other chronic diseases.
Official title: INcentives and ReMINDers to Improve Long-term Medication Adherence
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
550
Start Date
2025-04-02
Completion Date
2029-10-31
Last Updated
2025-09-11
Healthy Volunteers
No
Conditions
Interventions
Daily Text Messages
Participants will receive daily text message reminders to use their routine behavior to trigger medication adherence.
Incentivization based on timely ART adherence
Participants will be eligible to (draw a prize in monthly prize group) or get a monthly prize (monthly escalated group) if they take their medication within +/-one hour of the stated existing routine to which pill-taking is anchored on at least 80% of days for 3-months.
Locations (1)
Mildmay Uganda
Kampala, Uganda