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Hypofractionation for Prostate Cancer in Africa: A Feasibility Study
Sponsor: Muhimbili University of Health and Allied Sciences
Summary
Hypofractionated radiotherapy (HFRT) is a technique that delivers a higher radiation dose per treatment fraction over a shorter overall number of fractions, thus reducing the number of radiotherapy visits required to complete a course of radiation therapy. HFRT significantly alleviates the burden of transportation, accommodation, and income loss for patients while mitigating the strain on already limited healthcare personnel and infrastructure resources. Several randomized studies conducted in Europe and the USA have demonstrated that HFRT for prostate cancer is non-inferior to conventional radiotherapy in terms of toxicity and treatment outcomes. HypoAfrica Prostate Cancer is a multi-center study that aims to explore the feasibility of implementing moderate HFRT for the treatment of localized prostate cancer in Africa. In particular, this study will evaluate the gastrointestinal and genitourinary toxicities in prostate cancer patients for up to two years post-completion of HFRT.
Key Details
Gender
MALE
Age Range
18 Years - 90 Years
Study Type
OBSERVATIONAL
Enrollment
182
Start Date
2021-12-30
Completion Date
2029-03-01
Last Updated
2025-04-30
Healthy Volunteers
No
Conditions
Interventions
Hypofractionated radiotherapy for low- and intermediate-risk prostate cancer patients
Hypofractionated radiotherapy for low- and intermediate-risk prostate cancer will be treated with 20x3 Gray (Gy), 5 days/week
Hypofractionated radiotherapy for high-risk prostate cancer patients
Hypofractionated radiotherapy for high-risk prostate cancer will be treated with 20x3.1 Gy, 5 days/week
Locations (3)
NSIA-LUTH Cancer Center
Lagos, Lagos, Nigeria
Inkosi Albert Luthuli Central Hospital
Durban, South Africa
Ocean Road Cancer Institute
Dar es Salaam, Tanzania