Inclusion Criteria:
1. Infertile women aged between 35 and 42 years;
2. 0.1 ng/mL \<= AMH \<= 1.1 ng/ml;
3. Pregnancy aids who plan to perform in vitro fertilization and embryo transfer (antagonist program);
4. Bilateral ovaries are present;
5. Patients who voluntarily signed the informed consent and agreed to be followed up according to the requirements of the study protocol.
Exclusion Criteria:
1. Adenomyosis and uterine fibroids compression of uterine uterine line;
2. Untreated bilateral hydrosalpinx;
3. Uncured endometrial disease;
4. Any pregnancy occurred within 3 months before screening;
5. Patients with clinically significant abnormal cervical examination results within 3 months before screening;
6. Use of fertility regulators (such as clomiphene citrate, GnRH, metformin or oral contraceptives) within 1 month before randomization;
7. Use hormone drugs within 1 month before randomization;
8. Patients with acute infection of urinary and reproductive system;
9. Patients with major systemic diseases, endocrine or metabolic abnormalities that are not suitable to participate in this study, as judged by the investigator;
10. According to the judgment of the investigator, the presence of uterus (such as submucosal uterine fibroids, intermural uterine fibroids larger than 3 cm or smaller than 3 cm but affecting uterine cavity morphology, untreated endometrial polyps, uterine adhesions, uterine malformations, and ASRM stage Ⅲ-Ⅳ endometriosis). Patients with clinically significant ovarian (e.g., polycystic ovaries, ovarian cysts \> 4 cm, inability to retrieve eggs from both or one ovary) or adnexa (e.g., hydrosalpinx) abnormalities;
11. Patients with unexplained abnormal uterine bleeding;
12. Patients with a history of ovarian, breast, uterus, hypothalamus, pituitary and other malignant tumors;
13. Receive donor egg or embryo preimplantation genetic screening/embryo preimplantation genetic diagnosis (PGS/PGD);
14. Known past or current thromboembolic disease;
15. Have a known serious mental illness or fail to understand the purpose and methods of the clinical trial, or fail to comply with the study procedures;
16. Patients with contraindications or allergic history to the use of GnRH-a, r-hFSH, hCGα, progesterone;
17. Those who are addicted to alcohol, tobacco, drugs or drug abuse;
18. Being exposed to teratogenic amounts of radiation, poisons and drugs and in the action period;
19. Patients with liver function injury, that is, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were 2.5 times higher than the upper limit of normal values;
20. Persons who are HIV or syphilis positive;
21. Those with positive serum pregnancy tests;
22. Other reasons why the researcher considers it inappropriate to participate in the study. Suffers from a disease that is not suitable for the present assisted reproductive technology or for the present pregnancy;
23. Participants who had participated in other clinical trials within 3 months prior to screening.
