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Reproductive Outcomes After Intracytoplasmic Sperm Injection (ICSI) With Surgically Retrieved Sperm.
Sponsor: Karolinska Institutet
Summary
This research project explores how the source of sperm affects outcomes in assisted reproductive technologies (ART), focusing on children conceived through intracytoplasmic sperm injection (ICSI) with surgically retrieved sperm (SRS). Outcomes will be compared to those from ICSI with ejaculated sperm and conventional IVF. Using national registry data from all IVF and ICSI treatments in Sweden between 2007 and 2023 (Q-IVF), the study applies artificial intelligence (AI) and machine learning (ML) to identify factors influencing success rates. The aim is to improve prediction models and support more personalized fertility treatments. Special emphasis is placed on understanding the potential risks and long-term health outcomes for children conceived using SRS, which may be associated with higher rates of genetic abnormalities. The results may help optimize care strategies for infertile couples.
Official title: Reproductive Outcomes in Children Born Through Assisted Reproduction (ART): Focus on Intracytoplasmic Sperm Injection (ICSI) With Surgically Retrieved Sperm.
Key Details
Gender
All
Age Range
18 Years - 45 Years
Study Type
OBSERVATIONAL
Enrollment
200000
Start Date
2007-01-01
Completion Date
2027-05-30
Last Updated
2025-04-30
Healthy Volunteers
No
Interventions
IVF/ICSI
In vitro fertilization with or without ICSI with ejaculated and surgically retrieved sperm.
Locations (1)
Department of Clinical Science, Intervention and Technology, Division of Obstetrics and Gynaecology, Karolinska Institute
Stockholm, Sweden