Clinical Research Directory
Browse clinical research sites, groups, and studies.
Insulin Producing Stem Cell Transplantation Clinical Trial in Type 1 Diabetes
Sponsor: Ain Shams University
Summary
Type 1 Diabetes is a chronic autoimmune disease. It results from autoimmune destruction of pancreatic Beta cells leading to absolute insulin insufficiency. The establishment of pluripotent like human stem cells derived from adipose tissue derived mesenchymal cell origin have introduced a new potential source for cell therapy in type 1 diabetic patients, especially in light of recent successes in producing glucose-sensitive insulin secreting cells and this will be the scope of this study. In the last decade, human clinical trials of introducing insulin producing stem cells from various origins were approved and conducted.
Official title: Autologous Insulin Producing Mesenchymal Stem Cell Transplantation in Youth With Type 1 Diabetes
Key Details
Gender
All
Age Range
15 Years - 18 Years
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2025-04-01
Completion Date
2026-09-01
Last Updated
2025-04-30
Healthy Volunteers
No
Conditions
Interventions
Insulin producing stem cells infusion
1. Liposuction of the anterior abdominal subcutaneous fat layer of participant 2. Characterization and Identification of mesenchymal stem cells 3. Differentiation of mesenchymal stem cells into insulin producing stem cells 4. In vitro detection of Insulin and c-peptide in differentiated MSC (Confirmatory tests for the insulin producing cells) 5. In vitro Insulin and c-peptide release detection in differentiated MSC in response to increasing glucose concentrations Differentiated MSCs injection in human subjects 6. Followup
Locations (1)
Children Hospital Eldemerdash
Cairo, Egypt