Clinical Research Directory
Browse clinical research sites, groups, and studies.
Imaging Biomarkers of FOG Response to DBS
Sponsor: Medical University of South Carolina
Summary
For this study, the investigators are recruiting 54 individuals with Parkinson's Disease and Freezing of Gait (FOG) who are planning to undergo Deep Brain Stimulation (DBS). The objective of this study is to better understand the FOG response to DBS. Prior to DBS, participants will undergo an MRI scan, behavioral assessment related to walking, a cognitive evaluation, and assessment of other Parkinson's disease symptoms. Following DBS, participants will repeat these assessments at multiple timepoints over the period of one year. Overall, participants will complete a total of 7 visits over a period of approximately 1 year.
Official title: Imaging Biomarkers of Freezing of Gait Response to Deep Brain Stimulation
Key Details
Gender
All
Age Range
40 Years - Any
Study Type
INTERVENTIONAL
Enrollment
54
Start Date
2024-11-11
Completion Date
2030-01
Last Updated
2025-08-06
Healthy Volunteers
No
Interventions
fMRI
Baseline imaging will utilize advanced diffusion MRI metrics to determine which brain areas are structurally connected to the stimulation target and their structural integrity. Post-operative assessments will include behavioral measures of FOG response and imaging measures of neural response to stimulation. Pre- and post-operative data will be used to evaluate the association between structural integrity, connectivity and behavioral response.
Locations (1)
Medical University of South Carolina
Charleston, South Carolina, United States