Clinical Research Directory

Inclusion Criteria: * Age between 18 and 85 years; * Diagnosis of MCI; * Disease duration of less than 24 months from symptom onset; * Absence of malnutrition (diagnosed according to the NRS 2002 screening test) and with oral intakes sufficient to cover energy requirements (calculated by the Harris-Benedict formula, adjusted for activity factor and pathology); * Ability to understand and sign informed consent. Exclusion Criteria: * Patients on total or supplemental enteral nutrition * Severe dysphagia * Patients with glycated hemoglobin \> 8% * Patients on insulin therapy * Patients with poor beta-cell function (e.g., pancreasectomy, acute and chronic pancreatitis) * Patients with liver failure: MELD score \> 9 * Malnutrition (diagnosed according to the NRS 2002 screening test) and with per os intakes \< 60% of energy requirements (calculated using the Harris-Benedict formula, corrected for activity factor and pathology) * Metabolic disorders and/or enzyme disorders, dyslipidemia with total cholesterolemia \>300 mg/dl and/or triglyceridemia \>400 mg/dl) * Acute inflammatory disease or ongoing or recent (within 30 days) infectious states * Hypo- and hyperthyroidism not adequately compensated by treatment * Heart failure (NYHA III-IV), unstable angina, recent (\<6 months) acute cardiovascular or cerebrovascular events * Pregnancy or lactation * Neurological disorders other than MCI, psychiatric disorders * Nutrition and eating disorder * Alcohol abuse * Institutionalized patients * Participation in experimental therapies in the 2 months prior to enrollment * Allergy to MCT oil, nuts