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RECRUITING
NCT06952010
PHASE1

A Study of XB628 Alone and in Combination With Zanzalintinib in Participants With Recurrent Advanced or Metastatic Solid Tumors

Sponsor: Exelixis

View on ClinicalTrials.gov

Summary

This study consists of a Dose-Escalation stage and a Dose Expansion stage. The primary purpose of the dose escalation stage is to determine the maximum tolerated dose (MTD) and/or recommended dosage(s) for expansion (RDE\[s\]); and the dose expansion stage is to evaluate the preliminary antitumor activity of XB628 as a single agent and in combination with zanzalintinib.

Official title: A Phase 1 Dose Escalation and Expansion Study of XB628 as a Single Agent and in Combination With Zanzalintinib in Participants With Advanced or Metastatic Solid Tumors

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

303

Start Date

2025-05-01

Completion Date

2027-11-30

Last Updated

2026-06-24

Healthy Volunteers

No

Interventions

BIOLOGICAL

XB628

Intravenous infusion(s)

DRUG

Zanzalintinib

Oral tablet(s)

Locations (11)

Exelixis Clinical Site #5

San Francisco, California, United States

Exelixis Clinical Site #4

New Haven, Connecticut, United States

Exelixis Clinical Site #8

Tampa, Florida, United States

Exelixis Clinical Site #10

Boston, Massachusetts, United States

Exelixis Clinical Site #11

Boston, Massachusetts, United States

Exelixis Clinical Site #6

St Louis, Missouri, United States

Exelixis Clinical Site #7

New York, New York, United States

Exelixis Clinical Site #1

Hickory, North Carolina, United States

Exelixis Clinical Site #3

Nashville, Tennessee, United States

Exelixis Clinical Site #9

Houston, Texas, United States

Exelixis Clinical Site #2

San Antonio, Texas, United States