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A Study of XB628 Alone and in Combination With Zanzalintinib in Participants With Recurrent Advanced or Metastatic Solid Tumors
Sponsor: Exelixis
Summary
This study consists of a Dose-Escalation stage and a Dose Expansion stage. The primary purpose of the dose escalation stage is to determine the maximum tolerated dose (MTD) and/or recommended dosage(s) for expansion (RDE\[s\]); and the dose expansion stage is to evaluate the preliminary antitumor activity of XB628 as a single agent and in combination with zanzalintinib.
Official title: A Phase 1 Dose Escalation and Expansion Study of XB628 as a Single Agent and in Combination With Zanzalintinib in Participants With Advanced or Metastatic Solid Tumors
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
303
Start Date
2025-05-01
Completion Date
2027-11-30
Last Updated
2026-06-24
Healthy Volunteers
No
Interventions
XB628
Intravenous infusion(s)
Zanzalintinib
Oral tablet(s)
Locations (11)
Exelixis Clinical Site #5
San Francisco, California, United States
Exelixis Clinical Site #4
New Haven, Connecticut, United States
Exelixis Clinical Site #8
Tampa, Florida, United States
Exelixis Clinical Site #10
Boston, Massachusetts, United States
Exelixis Clinical Site #11
Boston, Massachusetts, United States
Exelixis Clinical Site #6
St Louis, Missouri, United States
Exelixis Clinical Site #7
New York, New York, United States
Exelixis Clinical Site #1
Hickory, North Carolina, United States
Exelixis Clinical Site #3
Nashville, Tennessee, United States
Exelixis Clinical Site #9
Houston, Texas, United States
Exelixis Clinical Site #2
San Antonio, Texas, United States