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Ultrasound Perfusion Estimation for Assessment of Peripheral Arterial Disease
Sponsor: Mayo Clinic
Summary
The purpose of this study is to develop a new noninvasive tool for early diagnosis of Peripheral Arterial Disease (PAD) and use the proposed method for monitoring the disease progression and the response to interventional treatment in PAD patients.
Official title: Ultrasound Perfusion Estimation for Assessment of PAD
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
400
Start Date
2025-03-14
Completion Date
2029-08-30
Last Updated
2025-05-01
Healthy Volunteers
Yes
Conditions
Interventions
Ultrasound Imaging
Non-invasive ultrasound will be performed using Angio Flow Reactivity Analysis (AFRA) The ultrasound probe will be attached to the subject's calf muscle and a pressure cuff will be secured around thigh. Ultrasound data will be collected for 1 minute. The cuff will then be induced to a tolerable pressure of no more than 160 mm Hg, and ultrasound data will be collected for 3 minutes while cuff is inflated. The cuff pressure will be released, and ultrasound data will be collected for 2 minutes after the release. Subject will be asked to perform 1 minute plantar flexion exercise, and ultrasound data will be collected for two minutes after the completion of exercise
Locations (1)
Mayo Clinic in Rochester
Rochester, Minnesota, United States