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RECRUITING
NCT06955221
NA

Effect of Alcohol Sclerotherapy on Pelvic Pain and Quality of Life in Women With Ovarian Endometriosis

Sponsor: Hospital Universitari de Bellvitge

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to evaluate whether ultrasound-guided alcohol sclerotherapy can improve pelvic pain and quality of life in women aged 18 to 45 diagnosed with ovarian endometriomas, compared to expectant management. The main questions it aims to answer are: 1. \- Does sclerotherapy significantly reduce pelvic pain compared to expectant management? 2. \- Does sclerotherapy improve quality of life as measured by the EHP-5 score? Researchers will compare the sclerotherapy group to the expectant management group to determine whether the intervention leads to greater improvement in pain and quality of life. Participants will: * Be randomly assigned to one of two groups: (1) Sclerotherapy group: undergo ultrasound-guided puncture and alcohol sclerotherapy; (2) Control group: expectant management * Complete quality of life and pain assessments at baseline and after 6 months * Provide blood and urine samples for biomarker analysis (e.g., cortisol, IL-6, hsCRP, catecholamines) * Undergo ovarian reserve assessments (AMH, antral follicle count) * Be followed for adverse events, recurrence, fertility outcomes, and treatment-related costs The study will follow an intention-to-treat and per-protocol analysis approach.

Official title: Effect of US-guided Alcohol Sclerotherapy for Endometriomas on Pelvic Pain and Quality of Life

Key Details

Gender

FEMALE

Age Range

18 Years - 45 Years

Study Type

INTERVENTIONAL

Enrollment

288

Start Date

2025-01-01

Completion Date

2027-12-31

Last Updated

2026-03-27

Healthy Volunteers

No

Interventions

PROCEDURE

Ultrasound-guided aspiration and alcohol sclerotherapy

Ultrasound-guided puncture and alcohol sclerotherapy

Locations (27)

Hospital Universitario Son Espases

Palma de Mallorca, Balearic Islands, Spain

Hospital Universitario Germans Trias i Pujol

Badalona, Barcelona, Spain

Hospital General de Granollers

Granollers, Barcelona, Spain

Consorci Sanitari de l'Anoia

Igualada, Barcelona, Spain

Consorci Sanitari Integral

L'Hospitalet de Llobregat, Barcelona, Spain

Hospital Universitario de Bellvitge

L'Hospitalet de Llobregat, Barcelona, Spain

Consorci Corporació Sanitària Parc Taulí

Sabadell, Barcelona, Spain

Parc Sanitari Sant Joan de Deu

Sant Boi de Llobregat, Barcelona, Spain

Hospital Universitari General de Catalunya

Sant Cugat del Vallès, Barcelona, Spain

Hospital de Viladecans

Viladecans, Barcelona, Spain

Hospital Universitario Doctor José Molina Orosa

Arrecife, Canary Islands, Spain

Hospital Universitario San Pedro

Logroño, La Rioja, Spain

Hospital General Universitario Los Arcos del Mar Menor

San Javier, Murcia, Spain

Hospital Universitario de Cabueñes

Gijón, Principality of Asturias, Spain

Hospital Universitario Central de Asturias

Oviedo, Principality of Asturias, Spain

Hospital Universitari Sant Joan de Reus

Reus, Tarragona, Spain

Hospital del Mar

Barcelona, Spain

Hospital Universitario de Burgos

Burgos, Spain

Hospital Universitario de Jaén

Jaén, Spain

Hospital Universitario Ramón y Cajal

Madrid, Spain

Hospital Clínico San Carlos

Madrid, Spain

Hospital Universitario 12 de Octubre

Madrid, Spain

Hospital Universitario Virgen del Rocío

Seville, Spain

Hospital Universitario Joan XXIII

Tarragona, Spain

Hospital Recoletas Salud Campo Grande

Valladolid, Spain

Hospital Clínico Universitario Lozano Blesa

Zaragoza, Spain

Hospital Universitario de Álava - Txagorritxu

Vitoria-Gasteiz, Álava, Spain