Clinical Research Directory

Inclusion Criteria: * PA conccurent with or without autonomous cortisol secretion * complete adrenalectomy * complete ACTH stimulation test on the one day after surgery * complete follow-up at 6，12 months after surgery Exclusion Criteria: * Patients underwent partial adrenalectomy * Suspicion of familial hyperaldosteronism or Liddle syndrome. \[i.e., age \<20 years, hypertension and hypokalemia, or with family history\] * Suspicion of pheochromocytoma or adrenal carcinoma. * Congestive heart failure with New York Heart Association (NYHA) Functional Classification III or IV; History of serious cardiovascular or cerebrovascular disease (angina, myocardial infarction or stroke) in the past 3 months; Severe anemia (Hb\<60g/L); Serious liver dysfunction or chronic kidney disease aspartate aminotransferase (AST) or alanine transaminase (ALT) \>3 times the upper limit of normal, or estimated glomerular filtration rate (eGFR) \< 30 ml/min/1.73 m2); Systemic Inflammatory Response Syndrome (SIRS); Uncontrolled diabetes (FBG≥13.3 mmol/L); Obesity (BMI≥35 kg/m2) or Underweight (BMI≤18 kg/m2); Untreated aneurysm; Other comorbidity potentially interfering with treatment; * Patients with actively malignant tumor. * Long- term use of glucocorticoids. * Suspected PBMAH or PPNAD;