Clinical Research Directory

Inclusion Criteria: 1. Have the ability to give informed consent, have signed informed and able to comply with the treatment plan to visit the tests and other procedural requirements 2. The age of signing the informed consent is from 18 to 75 years old, regardless of gender 3. Subjects with pathologically confirmed locally advanced unresectable or metastatic solid tumors 4. The ECOG score is 0 or 1 5. Expected survival ≥12 weeks 6. At least one measurable lesion according to RECIST v1.1 criteria 7. Good level of organ function 8. Male subjects whose partners are women of childbearing age and female subjects who are fertile are required to use highly effective contraceptive methods Exclusion Criteria: 1. subjects with uncontrolled or active brain metastasis； 2. subjects with clinical significant lung disease; 3. subjects with history of autoimmune diseases; 4. Known active hepatitis B or C infection; 5. Subjects with severe cardiovascular and cerebrovascular diseases 6. Uncontrolled tumor-related pain 7. Severe infections that require intravenous antibiotic, antiviral or antifungal control 8. Clinically symptomatic moderate to severe ascites; Uncontrollable or moderate or above pleural effusion, pericardial effusion 9. Received anti-tumor therapy 4 weeks prior to initiation of study treatment. 10. Known allergic to any compound of SHR-A2102 or HRS-4642 11. Other serious accompanying illnesses, which, in the investigator's assessment, could seriously adversely affect the safety of the treatment