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Multiphase Optimization Strategy (MOST) for Treating Pediatric Post-traumatic Stress Disorder (PTSD)
Sponsor: University of Rochester
Summary
The goal of this clinical trial is to test the extent to which different treatment components work to improve pediatric post-traumatic stress disorder (PTSD). It will also provide evidence for how these components work. The main research questions are: What are the effects of different components used to treat PTSD? What do these components change to produce benefits in PTSD? Researchers will: Compare components to a psychological placebo to estimate their effects and measure how they work Examine how components work alone and in conjunction with other components Participants will: Receive different combinations of components and placebo Attend weekly treatment sessions Provide information to evaluate changes in PTSD
Official title: Optimizing Behavioral Health Services Following Pediatric Trauma Exposure
Key Details
Gender
All
Age Range
8 Years - 17 Years
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2026-03-15
Completion Date
2028-08
Last Updated
2026-04-08
Healthy Volunteers
No
Conditions
Interventions
Emotion Regulation
Participants learn to reduce acute subjective distress, stabilize negative mood, promote positive mood, and alter physiological responses to trauma
Exposure
Participants engage in written exercises to reduce avoidance of trauma reminders and reinforce approach behaviors consistent with personal goals
Cognitive Processing
Participants learn ways to identify, challenge, and overcome the influence of cognitive distortions resulting from trauma exposure
Bi-lateral Stimulation
Participants engage in horizontal eye movements while recalling a traumatic memory and describing their affective and physiological state
Psychological Placebo
Participants receive non-directive support therapy, where they will guide the treatment session but not be required to discuss prior trauma exposure
Locations (1)
The Mt. Hope Family Center
Rochester, New York, United States