Clinical Research Directory

Inclusion Criteria: 1. Patients planning to undergo coronary revascularisation surgery within one month of study entry. 2. LVEF ≤45% by CMRI. 3. History of myocardial infarction at least 3 months prior to inclusion. 4. Scar covering at least 15% of the total left ventricular myocardial mass defined by late enhancement on CMRI. Exclusion Criteria: 1. Participation in another clinical trial within 30 days prior to inclusion. 2. Prior treatment with cell or gene therapy. 3. Be a candidate for heart transplant at the time of study entry. 4. Diagnosis of acute myocardial infarction with 3 months prior to inclusion. 5. Need for urgent revascularisation surgery. 6. Strict contraindication for the use of CMRI (pacemaker or implantable automatic defibrillator carriers, previous reactions to gadolinium contrast, claustrophobia, cochlear implants, etc.). 7. Presence of uncontrolled ventricular arrhythmias (ventricular tachycardia or ventricular fibrillation) at the time of implant surgery. 8. Active systemic infection. 9. Women who are pregnant or breastfeeding. 10. Mental disease or psychological condition that impedes the subject from understanding the nature of the protocol and granting his/her consent 11. Advanced dementia according to the Barthel index. 12. History of primary or acquired immunodeficiency or on immunosuppressive therapy (within 3 months prior to inclusion or if the need for immunotherapy is foreseeable at any time during the study follow up). 13. Tumour disease, except that eradicated at least 5 years prior to inclusion in the study and without receiving chest radiotherapy. Completely eradicated non melanoma skin tumours (at any time) not requiring chest chemotherapy or radiotherapy are permitted. 14. History of autoimmune disease. 15. Stroke within 12 months prior to inclusion. 16. Respiratory compromise or need for home oxygen therapy. 17. Life expectancy of less than 1 year for any reason