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Effect of Dexmedetomidine on Acute Kidney Injury After Ascending Aortic Surgeries
Sponsor: Ain Shams University
Summary
Acute kidney injury (AKI) is a frequent and serious complication after ascending aortic surgeries requiring cardiopulmonary bypass (CPB). Dexmedetomidine, a selective α-2 adrenoreceptor agonist, may reduce AKI because of its sympatholytic and anti-inflammatory effects against ischaemia reperfusion injury. We investigate the effect of dexmedetomidine administration on AKI after ascending aortic surgeries requiring CPB in a placebo-controlled randomised controlled trial.
Official title: Effect of Dexmedetomidine on Acute Kidney Injury After Ascending Aortic Surgeries: Placebo-controlled, Randomised Controlled Trial
Key Details
Gender
All
Age Range
21 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
78
Start Date
2025-05-01
Completion Date
2026-05-03
Last Updated
2025-05-07
Healthy Volunteers
Yes
Conditions
Interventions
Dexmedetomidine
the effect of dexmedetomidine administration on AKI after ascending aortic surgeries requiring CPB in a placebo-controlled randomised controlled trial.
Normal Saline (Placebo)
Group (B): the control group will receive an infusion of an equivalent volume of a 0.9% saline for the same duration
Locations (1)
AIN shams university
Cairo, Egypt, Egypt