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Therapeutic Strategies for Type 2 Diabetes Based on Lifestyle Changes: Plant-based Diet and Physical Exercise
Sponsor: Maria Elizabeth Rossi da Silva
Summary
The study evaluates the impact of a strict vegetarian diet combined with regular physical exercise and the use of probiotics on metabolic, inflammatory, and epigenetic parameters in patients with type 2 diabetes. It aims to determine the influence of these interventions on gut microbiota, glycemic control, body composition, insulin resistance, and quality of life.
Key Details
Gender
All
Age Range
45 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2022-11-22
Completion Date
2026-12
Last Updated
2025-05-18
Healthy Volunteers
No
Interventions
Probiotic Supplementation
Participants will follow the same strict vegetarian diet and regular physical exercise as in Intervention 1. Additionally, they will receive a probiotic supplement, taken twice daily for four weeks. This aims to evaluate the metabolic impact of probiotics in type 2 diabetes.
Placebo Administration
Participants will follow a strictly plant-based diet rich in fiber and bioactive compounds, with controlled macronutrient distribution. Regular physical exercise includes supervised aerobic and resistance training sessions. The intervention lasts four weeks. Instead of probiotic supplementation, participants will receive a placebo, administered in the same manner as the probiotic group to maintain blinding.
Locations (1)
Universidade de São Paulo (USP)
São Paulo, São Paulo, Brazil