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Depemokimab as an Extended Treatment Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation
Sponsor: GlaxoSmithKline
Summary
Depemokimab is being developed as a treatment for individuals with moderate to severe COPD. The aim of this study is to assess the efficacy and safety of depemokimab as an add-on medicine in participants with uncontrolled moderate to severe COPD with type 2 inflammation.
Official title: A Randomized, Double-Blind, Placebo- Controlled, Parallel-Group, Multicenter Study of the Efficacy and Safety of Depemokimab In Adult Participants With COPD With Type 2 Inflammation
Key Details
Gender
All
Age Range
40 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
981
Start Date
2025-06-20
Completion Date
2029-02-14
Last Updated
2026-10-05
Healthy Volunteers
No
Conditions
Interventions
Depemokimab
Depemokimab as a sterile liquid formulation will be administered.
Placebo
Placebo as a sterile 0.9 percent (%) sodium chloride solution will be administered.
Locations (281)
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Bakersfield, California, United States
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Modesto, California, United States
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Newport Beach, California, United States
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Wilmington, Delaware, United States
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Bradenton, Florida, United States
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Brandon, Florida, United States
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Hialeah, Florida, United States
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Hialeah, Florida, United States
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Loxahatchee Groves, Florida, United States
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Miami, Florida, United States
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Miami, Florida, United States
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Miami Lakes, Florida, United States
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Orange City, Florida, United States
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Palm Springs, Florida, United States
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Palmetto Bay, Florida, United States
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Pensacola, Florida, United States
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Tamarac, Florida, United States
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Tampa, Florida, United States
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The Villages, Florida, United States
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Riverdale, Georgia, United States
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Stonecrest, Georgia, United States
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Chicago, Illinois, United States
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Baltimore, Maryland, United States
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Clarkston, Michigan, United States
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Flint, Michigan, United States
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St Louis, Missouri, United States
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Henderson, Nevada, United States
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Las Vegas, Nevada, United States
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Reno, Nevada, United States
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North Massapequa, New York, United States
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Winston-Salem, North Carolina, United States
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Winston-Salem, North Carolina, United States
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Greenville, South Carolina, United States
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Rock Hill, South Carolina, United States
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Franklin, Tennessee, United States
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Corsicana, Texas, United States
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Dallas, Texas, United States
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Houston, Texas, United States
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Houston, Texas, United States
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Houston, Texas, United States
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McKinney, Texas, United States
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Pearland, Texas, United States
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La Plata, Provincia de Bs AS, Argentina
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Buenos Aires, Argentina
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Buenos Aires, Argentina
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Buenos Aires, Argentina
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Buenos Aires, Argentina
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Ciudad Autonoma de Bueno, Argentina
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Mendoza, Argentina
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Mendoza, Argentina
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Paraná, Argentina
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Rosario, Argentina
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San Juan Bautista, Argentina
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San Miguel de Tucumán, Argentina
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San Miguel de Tucumán, Argentina
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San Miguel de Tucumán, Argentina
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Aalst, Belgium
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Genk, Belgium
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Kortrijk, Belgium
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Liège, Belgium
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Liège, Belgium
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Namur, Belgium
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Sint-Niklaas, Belgium
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Richmond, British Columbia, Canada
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Ajax, Ontario, Canada
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Toronto, Ontario, Canada
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Windsor, Ontario, Canada
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Saint-Charles-Borromée, Quebec, Canada
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Sherbrooke, Quebec, Canada
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Saskatoon, Saskatchewan, Canada
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Curicó, Chile
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Haikou, Hainan, China
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Changsha, Hunan, China
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Chengdu, Sichuan, China
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Beijing, China
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Beijing, China
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Changchun, China
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Changchun, China
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Changsha, China
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Chengdu, China
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Chongqing, China
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Dongguan, China
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Fuyang, China
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Guangzhou, China
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Guangzhou, China
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Guilin, China
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Hangzhou, China
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Hangzhou, China
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Hefei, China
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Hohhot, China
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Hohhot, China
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Huizhou, China
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Huizhou, China
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Jiangmen, China
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Jiangmen, China
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Jiangsu, China
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Jiangxi, China
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Jinan, China
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Kunming, China
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Kunming, China
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Lianyungang, China
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Liuzhou, China
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Meizhou, China
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Mianyang, China
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Nanchang, China
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Nanchang, China
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Qingdao, China
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Qingyuan, China
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Qinhuangdao, China
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Shanghai, China
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Shanghai, China
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Shanghai, China
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Shanghai, China
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Suzhou, China
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Taiyuan, China
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Taizhou, China
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Ürümqi, China
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Weifang, China
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Wenzhou, China
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Wuhan, China
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Wuxi, China
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Xi'an, China
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Xiamen, China
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Xiamen, China
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Yinchuan, China
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Zhanjiang, China
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Zhengzhou, China
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Zigong, China
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Split, Croatia
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Zagreb, Croatia
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Roskilde, Region Sjælland, Denmark
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Aalborg, Denmark
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Hvidovre, Denmark
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Saint-Quentin, Aisne, France
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Marseille, Bouches-du-Rhône, France
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Amiens, France
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Blois, France
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Caen, France
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La Tronche, France
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Lyon, France
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Nice, France
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Pessac, France
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Toulouse, France
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Villeurbanne, France
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Löwenstein, Baden-Wurttemberg, Germany
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Donaustauf, Bavaria, Germany
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Peine, Lower Saxony, Germany
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Essen, North Rhine-Westphalia, Germany
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Ahrensburg, Germany
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Berlin, Germany
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Berlin, Germany
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Bonn, Germany
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Frankfurt am Main, Germany
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Frankfurt am Main, Germany
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Giessen, Germany
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Kiel, Germany
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Mainz, Germany
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München, Germany
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Wiesbaden, Germany
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Wuppertal, Germany
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Würzburg, Germany
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Budapest, Hungary
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Budapest, Hungary
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Pécs, Hungary
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Törökbálint, Hungary
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Dublin, Co. Dublin, Ireland
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Cork, Ireland
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Drogheda, Ireland
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Dublin, Ireland
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Galway, Ireland
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Mullingar, Ireland
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Kitakyushu-shi, Fukuoka, Japan
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Chiba, Japan
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Chiba, Japan
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Chiba, Japan
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Fukuoka, Japan
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Fukuoka, Japan
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Fukuoka, Japan
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Fukuoka, Japan
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Fukushima, Japan
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Gifu, Japan
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Hokkaido, Japan
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Hyōgo, Japan
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Hyōgo, Japan
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Hyōgo, Japan
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Hyōgo, Japan
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Hyōgo, Japan
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Ibaraki, Japan
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Ishikawa, Japan
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Kagawa, Japan
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Kanagawa, Japan
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Kanagawa, Japan
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Kanagawa, Japan
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Kyoto, Japan
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Mie, Japan
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Mie, Japan
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Nankoku-shi, Japan
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Niigata, Japan
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Niigata, Japan
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Okayama, Japan
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Omuta Shi, Japan
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Osaka, Japan
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Osaka, Japan
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Osaka, Japan
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Shizuoka, Japan
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Shizuoka, Japan
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Shizuoka, Japan
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Shizuoka, Japan
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Shizuoka, Japan
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Tokyo, Japan
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Tokyo, Japan
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Tokyo, Japan
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Tokyo, Japan
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Tokyo, Japan
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Tokyo, Japan
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Tokyo, Japan
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Yamaguchi, Japan
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Yokohama, Japan
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Zutphen, Gelderland, Netherlands
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Breda, North Brabant, Netherlands
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Zwolle, Overijssel, Netherlands
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Deventer, Netherlands
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Enschede, Netherlands
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Harderwijk, Netherlands
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Hoofddorp, Netherlands
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Nijmegen, Netherlands
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Lørenskog, Akershus, Norway
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Poznan, Greater Poland Voivodeship, Poland
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Katowice, Silesian Voivodeship, Poland
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Bialystok, Poland
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Bydgoszcz, Poland
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Krakow, Poland
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Poznan, Poland
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Rzeszów, Poland
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Rzeszów, Poland
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Wroclaw, Poland
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Loures, Lisbon District, Portugal
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Senhora da Hora, Porto District, Portugal
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Almada, Setúbal District, Portugal
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Guarda, Portugal
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Lisbon, Portugal
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Lisbon, Portugal
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Lisbon, Portugal
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Setúbal, Portugal
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Vila Nova de Gaia, Portugal
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Košice, Slovakia
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Spišská Nová Ves, Slovakia
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Pozuelo de Alarcón, Madrid, Spain
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Marbella, Málaga, Spain
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Alzira, Spain
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Barcelona, Spain
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Benalmádena, Spain
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Ferrol, Spain
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GaldakaoVizcaya, Spain
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Madrid, Spain
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Madrid, Spain
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Marbella, Spain
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Málaga, Spain
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Málaga, Spain
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Palma de Mallorca, Spain
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Santander, Spain
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Seville, Spain
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Zaragoza, Spain
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Lund, Sweden
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Stockholm, Sweden
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Stockholm, Sweden
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Aarau, Switzerland
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Zurich, Switzerland
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Changhua, Taiwan
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Kaohsiung City, Taiwan
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Taichung, Taiwan
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Taichung, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Izmir, Balcova, Turkey (Türkiye)
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Antalya, Konyaaltı, Turkey (Türkiye)
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Denizli, Pamukkale, Turkey (Türkiye)
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Çanakkale, Turkey (Türkiye)
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İzmit, Turkey (Türkiye)