Inclusion Criteria:
* Patients are eligible for the study if they meet all of the following criteria:
1. Prior to enrollment, the participant is required to sign a written informed consent form.
2. Participants should be above 18 years，regardless of gender.
3. Histopathologically confirmed untreated advanced colorectal adenocarcinoma.
4. Tumors with RAS (KRAS, NRAS, HRAS) and BRAF wild-type, MSS phenotype, excluding appendiceal or anal cancer. All listed codons must be wild-type: KRAS: Exons 2, 3, 4 (Codons 12, 13, 59, 61, 117, 146) ; NRAS: Exons 2, 3, 4 (Codons 12, 13, 59, 61, 117, 146)
5. Imaging (enhanced CT/MRI/PET-CT) confirms advanced/metastatic colorectal cancer with measurable lesions according to RECIST v1.1.
6. No prior systemic therapy for advanced/metastatic colorectal cancer, including chemotherapy, EGFR inhibitors (cetuximab, panitumumab), VEGF inhibitors (bevacizumab), and immune checkpoint inhibitors (anti-PD-1/PD-L1/CTLA-4). Adjuvant/neoadjuvant chemotherapy within 6 months before recurrence/metastasis is considered first-line therapy.
7. ECOG PS score 0-1.
8. Expected survival \>12 weeks.
9. Adequate organ function (without blood component or growth factor use within 14 days):
Hematology:Neutrophils ≥1.5×10⁹/L, platelets ≥100×10⁹/L, hemoglobin ≥90 g/L. Liver/kidney function: SCr ≤1.5×ULN or creatinine clearance ≥50 ml/min, TBIL ≤1.5×ULN, AST/ALT ≤2.5×ULN (≤5×ULN if due to liver metastasis), urine protein \<2+ (≤1g/24h if ≥2+).
10. Normal coagulation, no active bleeding/thrombosis: INR ≤1.5×ULN, APTT ≤1.5×ULN, PT ≤1.5×ULN.
11. Non-surgically sterile women of childbearing potential must use contraception during and 3 months after treatment; serum/urine HCG negative within 7 days before enrollment; not breastfeeding. Non-surgically sterile men must use contraception with partners during and 3 months after treatment.
12. Willing participant with good compliance for safety and survival follow-up.
Exclusion Criteria:
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* Patients will be excluded from the study if they meet any of the following exclusion criteria:
1. Other malignancies in the past or current (excluding cured basal cell carcinoma or cervical carcinoma in situ).
2. Current duodenal ulcer, ulcerative colitis, intestinal obstruction, or other GI conditions that may cause bleeding or perforation, as judged by the investigator.
3. Patients with symptomatic pleural, peritoneal, or pericardial effusions requiring treatment.
4. History of allergy to monoclonal proteins or any component of the study drugs.
5. Oral traditional Chinese medicine, immunomodulators within 2 weeks, or radiotherapy within 4 weeks before treatment.
6. Thyroid dysfunction that is uncontrolled by medication.
7. Uncontrolled hypertension despite receiving optimal treatment (systolic BP\>150 mmHg or diastolic BP\>90 mmHg).
8. Uncontrolled cardiac conditions: (1) NYHA Class II+ heart failure; (2) unstable angina; (3) myocardial infarction within 1 year; (4) clinically significant arrhythmias requiring treatment.
9. Active autoimmune disease or a history of such diseases.
10. Immunosuppressants, systemic, or absorbable topical steroids for immunosuppression (\>10 mg/day prednisone or equivalent) within 2 weeks before enrollment.
11. CNS metastases.
12. Active infection or unexplained fever\>38.5°C during screening or before first dose (tumor-related fever is acceptable).
13. History or current evidence of pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, radiation pneumonitis, drug-induced pneumonia, or severe pulmonary dysfunction.
14. Congenital or acquired immunodeficiency, such as HIV infection, or active hepatitis (elevated transaminases not meeting inclusion criteria, HBV DNA≥1000 IU/ml, HCV RNA≥1000 IU/ml).
15. Live vaccine administration within 4 weeks before first dose or planned during the study.
16. History of psychiatric drug abuse, alcoholism, or drug addiction.
17. Pregnant or breastfeeding women, or those planning pregnancy during the trial.
18. Any other factor that may lead to premature study discontinuation, as judged by the investigator.
