Clinical Research Directory
Browse clinical research sites, groups, and studies.
Cognitive Decline Following Deep Brain Stimulation: A DBS-fMRI Study
Sponsor: Medical University of South Carolina
Summary
The objective of this research study is to understand how Deep Brain Stimulation (DBS) targeting the subthalamic nucleus (STN) affects cognitive networks in the brain, potentially leading to cognitive decline in patients with Parkinson's Disease (PD). A total of 55 participants with PD who have undergone DBS surgery will be recruited from MUSC's Clinical DBS Program. Participants will attend two post-DBS visits: a 3-hour visit for consent, demographic, and cognitive assessments, and a 3-hour DBS-MRI visit to evaluate brain network connectivity with stimulation ON and OFF. These findings will help improve patient selection for surgery and optimize the selection of stimulation targets that minimize undesirable cognitive side effects.
Official title: A Neural Basis for Cognitive Decline Following Deep Brain Stimulation: A DBS-fMRI Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
55
Start Date
2025-08-21
Completion Date
2028-04-01
Last Updated
2025-10-14
Healthy Volunteers
Yes
Conditions
Interventions
DBS combined with fMRI
Participants will undergo fMRI scanning while their DBS device is either turned OFF or ON. BOLD (blood oxygen level dependent) changes in response to DBS will be evaluated across PD participants. These scans and DBS procedure will be used for research purposes only and are not for treatment or diagnostic purposes.
Locations (1)
Medical University of South Carolina
Charleston, South Carolina, United States