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Two Versus One Week Breast Radiotherapy (RT)
Sponsor: Weill Medical College of Cornell University
Summary
This study is comparing two different radiation therapy approaches for early breast cancer to see which one is better for patients. One group will receive radiation over one week (based on the FAST-FORWARD trial), and the other group will receive radiation over two weeks with an extra focused dose (called a "concomitant boost"). The study will look at how the treatments affect side effects, breast appearance, and cancer control in the breast. It also aims to find out if the two-week treatment does a better job at preventing cancer from coming back in the breast over the long term.
Official title: Prospective Randomized Trial of Two Versus One Week Accelerated Radiotherapy (PRATO)
Key Details
Gender
FEMALE
Age Range
Any - Any
Study Type
INTERVENTIONAL
Enrollment
400
Start Date
2025-04-29
Completion Date
2040-12-31
Last Updated
2025-07-25
Healthy Volunteers
No
Conditions
Interventions
Radiation therapy - 1 week
2600 cGy whole breast radiotherapy in five fractions (Arm 1) over 1 week
Radiation therapy - 2 weeks
3200 cGy whole breast radiotherapy with a concomitant tumor bed boost to 3600 cGy in 10 fractions (Arm 2) over 2 weeks. In Arm 2, if no cavity is visible due to oncoplastic surgery, we will deliver 32 Gy to the whole breast only, without a boost.
Locations (3)
Brooklyn Methodist Hospital
New York, New York, United States
New York Presbyterian Hospital
New York, New York, United States
New York-Presbyterian Weill Cornell Medical College
New York, New York, United States