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Effects of Oral Propranolol on Induction-Delivery Interval During Induction of Labour With Oxytocin
Sponsor: Federal Teaching Hospital Abakaliki
Summary
Prolonged pregnancy could lead to perinatal and maternal complications. Oxytocin has been wildly used for induction of labour, but prolonged labour continued to occur with its attendant sequelae. Propranolol, a non-selective B-adrenergic inhibitor has been found to facilitate labour progress in some studies, by the blockade of the effects of catecholamines on the uterus though there are conflicting reports, with the only meta-analysis inconclusive due to few studies used; hence, the need to further study its role in induction of labour. The aim of this study is to assess the role of oral Propranolol in decreasing the induction-delivery with oxytocin
Official title: A Randomized Controlled Trial on the Effect of Oral Propranolol on Induction-Delivery Interval in Women Undergoing Oxytocin Induction of Labour in Abakaliki
Key Details
Gender
FEMALE
Age Range
15 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
308
Start Date
2025-06-01
Completion Date
2025-12-01
Last Updated
2025-05-07
Healthy Volunteers
Yes
Conditions
Interventions
Propranolol
A set of 154 numbers will receive oxytocin and propranolol once or twice 6 hours apart. the first dose will be from 10 minutes before commencement of oxytocin titration and the second dose will be 6 hours from the first dose if delivery has not taken place.
Placebo
A set of 154 numbers will receive oxytocin and placebo once or twice 6 hours apart. the first dose will be from 10 minutes before commencement of oxytocin titration and the second dose will be 6 hours from the first dose if delivery has not taken place.
Locations (1)
Alex Ekwueme Federal University Teaching Hospital
Abakaliki, Ebonyi State, Nigeria