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A Study Evaluating the Efficacy and Safety of ALG-000184 Compared With Tenofovir Disoproxil Fumarate in Untreated HBeAg-Positive and HBeAg- Negative Adult Subjects With Chronic Hepatitis B (B-SUPREME)
Sponsor: Aligos Therapeutics
Summary
This is a Phase 2 study to evaluate efficacy and safety of 48 weeks of oral once daily monotherapy with ALG-000184 versus tenofovir disproxil fumarate (TDF) for chronic HBV infection.
Official title: A Randomized, Double-Blind, Active-Controlled Multicenter Phase 2 Study Evaluating the Efficacy and Safety of ALG-000184 Compared With Tenofovir Disoproxil Fumarate in Untreated HBeAg-Positive and HBeAg-Negative Adult Subjects With Chronic Hepatitis B Virus Infection (B-SUPREME)
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2025-07-15
Completion Date
2028-08
Last Updated
2026-02-06
Healthy Volunteers
No
Conditions
Interventions
ALG-000184
300 mg tablet
TDF
300 mg tablet
Locations (57)
Aligos Investigational Site
Chandler, Arizona, United States
Aligos Investigational Site
Coronado, California, United States
Aligos Investigational Site
Garden Grove, California, United States
Aligos Investigational Site
Los Angeles, California, United States
Aligos Investigational Site
Palo Alto, California, United States
Aligos Investigational Site
Pasadena, California, United States
Aligos Investigational Site
Rialto, California, United States
Aligos Investigational Site
San Francisco, California, United States
Aligos Investigational Site
San Jose, California, United States
Aligos Investigational Site
Miami, Florida, United States
Aligos Investigational Site
Miami, Florida, United States
Aligos Investigational Site
Marrero, Louisiana, United States
Aligos Investigational Site
Baltimore, Maryland, United States
Aligos Investigational Site
Chevy Chase, Maryland, United States
Aligos Investigational Site
Boston, Massachusetts, United States
Aligos Investigational Site
Manhasset, New York, United States
Aligos Investigational Site
New York, New York, United States
Aligos Investigational Site
Durham, North Carolina, United States
Aligos Investigational Site
Sliven, Bulgaria
Aligos Investigational Sites
Sofia, Bulgaria
Aligos Investigational Site
Stara Zagora, Bulgaria
Aligos Investigational Site
Edmonton, Canada
Aligos Investigational Site
Ottawa, Canada
Aligos Investigational Site
Toronto, Canada
Aligos Investigational Sites
Vancouver, Canada
Aligos Investigational Sites
Beijing, China
Aligos Investigational Site
Chengdu, China
Aligos Investigational Site
Chongqing, China
Aligos Investigational Sites
Guangzhou, China
Aligos Investigational Site
Nanjing, China
Aligos Investigational Sites
Shanghai, China
Aligos Investigational Site
Clichy, France
Aligos Investigational Site
Limoges, France
Aligos Investigational Site
Nice, France
Aligos Investigational Site
Rennes, France
Aligos Investigational Site
Rouen, France
Aligos Investigational Site
Toulouse, France
Aligos Investigational Sites
Hong Kong, Hong Kong
Aligos Investigational Site
Milan, Italy
Aligos Investigational Site
Chisinau, Moldova
Aligos Investigational Site
Auckland, New Zealand
Aligos Investigational Sites
Bucharest, Romania
Aligos Investigational Site
Ansan, South Korea
Aligos Investigational Site
Busan, South Korea
Aligos Investigational Sites
Seoul, South Korea
Aligos Investigational Site
Ulsan, South Korea
Aligos Investigational Site
Yangsan, South Korea
Aligos Investigational Site
Barcelona, Spain
Aligos Investigational Site
Pontevedra, Spain
Aligos Investigational Site
Chiayi City, Taiwan
Aligos Investigational Site
Kaohsiung City, Taiwan
Aligos Investigational Site
Taichung, Taiwan
Aligos Investigational Site
Tainan, Taiwan
Aligos Investigational Site
Taipei, Taiwan
Aligos Investigational Site
Glasgow, United Kingdom
Aligos Investigational Site
Leicester, United Kingdom
Aligos Investigational Sites
London, United Kingdom