Clinical Research Directory

Inclusion Criteria: * Clinical diagnosis of lipedema: increased lowe-limb volume, disproportion between upper and lower body, and pain. * Lipedema type III stages 1 or 2. * Negative pitting sign. * In maintenance treatment phase with a class II circular-knitted compression garment for at least 6 months. * Adequate compliance with compression garments (worn during the day, except during personal hygiene and water-related activities). * Written informed consent to participate. Exclusion Criteria: * Lipedema with fatty lobulations. * Body Mass Index (BMI) ≥ 30 kg/m2. * Waist-to-Height Ratio \> 0.53. * Pregnancy. * Renal, hepatic, or cardiac insufficiency. * Thrombosis in the lower extremities. * Infection in the lower extremities. * Active oncological process. * Current treatment with corticosteroids and other medications that promote fluid retention. * Inability to read the Patient Information Form (HIP) and/or provide consent to participate in the study.