Awake Prone Positioning of Patients Suffering Community Acquired Pneumonia Requiring Nasal High Flow Therapy

NOT YET RECRUITING

NCT06966310

NA

Sponsor: University Hospital, Tours

Summary

Community acquired pneumonia, in particular when requiring oxygen therapy because of acute hypoxemic respiratory failure and meeting acute respiratory distress syndrome (ARDS) criteria frequently leads to tracheal intubation and poor outcome. Among invasively mechanically ventilated patients with ARDS and presenting a PaO2/FiO2 ratio (arterial partial pressure of oxygen to inspired fraction of oxygen) of less than 150 mmHg, the prone position significantly reduces mortality and represents standard care (Guérin 2013). Among non-intubated COVID-19 patients, a subtype of viral community acquired pneumonia, a recent study showed that awake prone positioning reduces the composite outcome of intubation or death among patients requiring nasal high flow therapy. Furthermore, it favored weaning of nasal high flow therapy. Prone position in patients with non-COVID ARDS treated with high nasal flow was evaluated in 20 patients with predominantly viral pneumonia (Ding 2020) and was associated with improved oxygenation. We hypothesize that prone positioning of patients suffering non-COVID community acquired pneumonia and undergoing nasal high flow therapy can significantly improve outcome by reducing the need for intubation and associated therapies such as sedation and muscle relaxation.

Official title: Awake Prone Positioning of Patients Suffering Community Acquired Pneumonia Requiring Nasal High Flow Therapy, Excluding COVID-19

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

1078

Start Date

2025-05-19

Completion Date

2034-04

Last Updated

2025-05-11

Healthy Volunteers

No

Conditions

Community-acquired Pneumonia

Interventions

OTHER

Prone position

depending on tolerance, the objective is to spend as much time as possible, up to 16h and beyond, in prone position per period of 24 hours. For each session the patients will be encouraged to stay as long as possible in the prone position (i.e. ideally 4-8 hours each session).

Locations (38)

Intensive care, University Hospital, Amiens

Amiens, France

Intensive care, University Hospital, Angers

Angers, France

Intensive care, University Hospital, Argenteuil

Argenteuil, France

Intensive care, University Hospital, Belfort

Belfort, France

Intensive care, University Hospital, Besancon

Besançon, France

Intensive care, University Hospital, Bethune

Béthune, France

Intensive care, University Hospital, Blois

Blois, France

Intensive care, University Hospital, Bordeaux

Bordeaux, France

Intensive care, University Hospital, Bourg en Bresse

Bourg-en-Bresse, France

Intensive care, University Hospital, Bourges

Bourges, France

Intensive care, University Hospital, Brest

Brest, France

Intensive care, University Hospital, Colombes

Colombes, France

Intensive care, University Hospital, Dieppe

Dieppe, France

Intensive care, University Hospital, Dijon

Dijon, France

Intensive care, University Hospital, Dreux

Dreux, France

Intensive care, University Hospital, Garches

Garche, France

Intensive care, University Hospital, Grenoble

Grenoble, France

Intensive care, University Hospital, La Roche sur Yon

La Roche-sur-Yon, France

Intensive care, University Hospital, Le Mans

Le Mans, France

Intensive care, University Hospital, Lens

Lens, France

Intensive care, University Hospital, Lille

Lille, France

Intensive care, University Hospital, Lorient

Lorient, France

Intensive care, University Hospital, Lyon

Lyon, France

Intensive care, University Hospital, Lyon

Lyon, France

Intensive care, University Hospital, Morlaix

Morlaix, France

Intensive care, University Hospital, Nantes

Nantes, France

Intensive care, University Hospital, Nice

Nice, France

Intensive care, University Hospital, Nice

Nice, France

Intensive care, University Hospital, Orléans

Orléans, France

Intensive care, University Hospital, Cochin

Paris, France

Intensive care, University Hospital, Tenon

Paris, France

Intensive care, University Hospital, Poitiers

Poitiers, France

Intensive care, University Hospital, Rouen

Rouen, France

Intensive care, University Hospital, Saint Brieuc

Saint-Brieuc, France

Intensive care, University Hospital, Saint Nazaire

Saint-Nazaire, France

Intensive care, University Hospital, Strasbourg

Strasbourg, France

Intensive care, University Hospital, Strasbourg

Strasbourg, France

Intensive care, University Hospital, Tours

Tours, France

Clinical Research Directory