Clinical Research Directory

Inclusion Criteria: 1. Consent to participate in the clinical trial, and the trial subject and/or legal guardian has signed the informed consent form. 2. Age 1-14 years, no gender restrictions. 3. Compliant with the diagnostic criteria for focal seizures and focal-to-bilateral tonic-clonic seizures as outlined by the International League Against Epilepsy (ILAE) in 2017. 4. Stable on one antiepileptic drug for ≥4 weeks, and deemed to be appropriate for the addition of zonisamide therapy by the investigator. 5. ≥ 2 episodes of generalized tonic-clonic seizures （secondary to focal epileptic seizures) per 28-day interval during the 8-week retrospective baseline period. Exclusion Criteria: 1. History of zonisamide treatment. 2. History of allergy to sulfonamide drugs, zonisamide or any excipients. 3. History of drug/alcohol abuse. 4. History of suicide attempt or suicidal ideation within the past 6 months. 5. Current use of antidepressants, anxiolytics, or antipsychotics. 6. Diagnosed with progressive diseases affecting the brain and its functions. 7. Psychogenic non-epileptic seizures. 8. Diagnosed with severe pulmonary/hematologic diseases, malignant tumors, immunodeficiency, or psychiatric illnesses. 9. Have undergone epilepsy brain surgery or plan to undergo epilepsy surgery within the next 4 months. 10. Deemed to be unsuitable for participation in the trial by the investigator.