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Epidemiological Factors and Optimization of Conservative Approaches to Precancerous Lesions of Female Reproductive Organs
Sponsor: Nikola Janovska
Summary
The primary aim of this study is to develop a recommended clinical practice guideline for managing women with HPV HR (high-risk human papillomavirus) positivity and cervical lesions. Additionally, in collaboration with the Bioptic Laboratory, the study will analyze the integration of HPV HR testing into screening programs for women aged 35, 45, and 55, with a focus on optimizing management strategies for HPV HR-positive women. Research Objectives: * Evaluate spontaneous regression/progression over two years based on HPV HR genotyping (three groups - according to Alinity: high, intermediate, and low risk). * Assess spontaneous regression/progression over two years based on HPV HR genotyping and viral load in HPV-vaccinated vs. non-vaccinated patients. * Evaluate spontaneous regression/progression over two years based on methylation results. * Assess spontaneous regression/progression over two years based on CinTec plus results.
Key Details
Gender
FEMALE
Age Range
18 Years - 46 Years
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2024-11-01
Completion Date
2029-12
Last Updated
2025-07-31
Healthy Volunteers
No
Conditions
Locations (1)
University Hospital Kralovske Vinohrady
Prague, Czechia