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Spatiotemporal Thalamocortical Alterations Underlie Experimental and Chronic Pain
Sponsor: The University of Texas Health Science Center, Houston
Summary
The purpose of this study is to assess thalamocortical (TC) connectivity during tonic pressure pain, to evaluate alpha activity during tonic pressure pain and to determine pressure pain ratings by using Electroencephalography (EEG), Functional Magnetic Resonance Imaging (fMRI), Transcranial Alternating Current Stimulation (tACS), sham and Transcranial random noise stimulation (tRNS)
Official title: Spatiotemporal Thalamocortical Alterations Underlie Experimental and Chronic Pain - Phase II
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2025-06-01
Completion Date
2028-02-29
Last Updated
2026-03-02
Healthy Volunteers
Yes
Conditions
Interventions
transcranial alternating current stimulation (tACS)
Participants will get a personalized brain stimulation: a 2 milliampere (mA) oscillating current that matches their natural alpha brain wave frequency (8-12 Hz), determined by a quick 3-minute EEG before the session.
Sham
Active sham stimulation with 60- second -tACS will be applied , then ramp down, and be reintroduced in the last 30 seconds to minimize awareness of the experimental condition
transcranial random noise stimulation (tRNS)
Participants will still get stimulation, but at random frequencies between 1 and 200 Hz (instead of targeted alpha waves).
Locations (1)
The University of Texas Health Science Center at Houston
Houston, Texas, United States