Clinical Research Directory

Inclusion Criteria: * male or female * aged 18-75 years old * fulfill Rome IV criteria for functional constipation * have not participated in similar research in the past three months Exclusion Criteria: * Personal or family history of colon cancer, celiac disease, and inflammatory bowel disease * Irritable bowel syndrome diagnosed during colonoscopy * Those who are pregnant recently (including men and women), or are pregnant or breastfeeding women. * Taking antidepressants, anti-anxiety drugs and other psychotropic drugs. * Long-term medication is required to improve constipation * Those diagnosed with myocardial infarction, cerebral infarction, malignant tumor and/or other serious diseases are not suitable for participating in the study. * Allergic symptoms to probiotics or any ingredients * Having a history of serious mental illness * Drug-related crimes or alcohol problems * Have recently traveled to areas where parasitic diseases are prevalent.